Adriamycins and uses thereof

Details Adriamycins and uses thereof Adriamycins and uses thereof

1975-03-19

1977-11-15

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

2603409R, 536 4, 536 17, 536 18, 536 53, A61K 3170, C07H 1524

Patent

active

040585190

ABSTRACT:
The known antitumor antibiotic adriamycin and its .beta.-anomer, and the novel compounds, 4'-epiadriamycin (both .alpha.- and .beta.-anomers) are prepared by condensing a novel, reactive protected derivative of adriamycinone with reactive intermediates which are 1-halo-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxy-.alpha.-L-ly xo (or arabino) hexopyranoses.

REFERENCES:
patent: 3356674 (1967-12-01), Ikeda et al.
patent: 3427300 (1969-02-01), Sarett et al.
patent: 3590028 (1971-06-01), Arcamone et al.
patent: 3629231 (1971-12-01), Hough et al.
patent: 3651090 (1972-03-01), Hardie et al.
patent: 3803124 (1974-04-01), Arcamone et al.
Pigman, "The Carbohydrates", Academic Press, Inc., New York, N. Y., 1957, pp. 42, 49, 50.
Arcamone et al., "Chem. Abst." vol. 74, 1971.

Affiliated with

Also associated with

Rating

Adriamycins and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Adriamycins and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Adriamycins and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1719451