Adrenocorticotropin release inhibiting factor

Details Adrenocorticotropin release inhibiting factor Adrenocorticotropin release inhibiting factor

1988-07-11

1991-08-27

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514805, A61K 3702

Patent

active

050433210

ABSTRACT:
A method for alleviating stress induced immunosuppression is accomplished by application of low doses of ANF[1-28] or other ANF analogs having intact N-terminal sequences. Atrial natriuretic factors (ANFs) with intact N-terminal sequences are shown to be effective inhibitors of CRF 41-stimulated ACTH secretion when the ANFs are present in low concentrations. ANF[1-28] significantly inhibited ACTH release stimulated by 1-5 nM CRF. At the most effective concentration of 100 pM, ACTH release was inhibited by 40.1% (p<0.001). This effect was manifested after three hours, but not after only one half or one hour of incubation. Conversely, ANF[5-28], at concentrations of 10 to 10,000 pM, had no effect on ACTH secretion after one half, one, or three hours. ANF[1-11] weakly inhibited ACTH secretion at concentrations of 100 pM and 1000 pM. Again, three hours of incubation was required to manifest these effects.

REFERENCES:
patent: 4605642 (1986-08-01), Rivier et al.
patent: 4607023 (1986-08-01), Thibault et al.
patent: 4643989 (1987-02-01), Baird
patent: 4663437 (1987-05-01), de Bold
Rudinger, Peptide Hormones, Parsons (Ed.), U. Park Press, Baltimore, pp. 1-7, (1976).
Talmadge et al., 13th International Congress of Chemotherapy, Spitzy et al., (Ed.) Proceedings, pp. 203/19-203/35 (1983).
Takao et al., Life Sciences, vol. 42, pp. 1199-1203 (1988).
Anand-Srivastava et al., Life Sciences, vol. 36, pp. 1873-1879 (1985).
King et al., Soc Neurosci Abstr. 14(2), p. 1285 (1988).
Vale et al., Science, vol. 213, pp. 1394-1397, (1981).
Atlas et al., Ann. Rev. Med., vol. 37, pp. 397-414 (1986).
Ballerman et al., Cir. Res. vol. 58, pp. 619-630 (1986).
Grenest et al., Circulation, vol. 75, pp. I118-124 (1/87).
Peninsula Labs. Catalog, pp. 1, 31-33, Belmont, California, (1990-1991).
R. Hashimoto et al., Regulatory Peptides, 17:53 (1987).
S. Baertschi et al., Int. Cong. Neuroendocrin., San Francisco (1987).
T. Abou-Samra et al., Endocrinology, 120:18 (1987).
U. Heisler et al., Mol. Cell. Endocrinol., 44:125 (1986).
V. Simard et al., Regulatory Peptides, 15:269 (1986).
W. Shibasaki et al., Biochem. Biophys. Res. Comm., 135:1035 (1986).
X. Hattori et al., Endocrinol. Japan., 33:533 (1986).
Y. Okajima et al., Horm. Metab. Res. 18:497 (1986).
Z. Rosenthal et al., Life Sciences, 40:1179 (1987).
Z. Graham et al., Atrial Natriuretic Factor, Chapter 65 (1987).

Affiliated with

Also associated with

Rating

Adrenocorticotropin release inhibiting factor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Adrenocorticotropin release inhibiting factor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Adrenocorticotropin release inhibiting factor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1414209