Adrenergic receptor

Details Adrenergic receptor Adrenergic receptor

1995-06-06

1998-10-06

Walsh, Stephen

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound other than saccharide containing a...

536 235, 435325, 4353201, 4352523, C12D 2102

Patent

active

058174770

ABSTRACT:
A human adrenergic receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are agonists for the adrenergic receptor polypeptide which may be used therapeutically to stimulate the adrenergic receptor and antagonist inhibitors against such adrenergic receptor polypeptides and their use therapeutically to antagonize the adrenergic receptor. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.

REFERENCES:
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patent: 5288607 (1994-02-01), Emorine et al.
PCT International Search Report.
Granneman, et al., Molecular Pharmacology, 40:895-899 (1991).
Lomasney, et al., The Journal of Biological Chemistry, 266(10):6365-6369 (1991).
Fraser, et al., The Journal of Biological Chemistry, 264(20):11754-11761 (1989).
Milano, et al., Science, 264:582-586 (1994).
Strader, Cell, 49:855-863 (1987).
Seachrist, L., 264:507-508 (1994).

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