Adrenergic blocking agents

Details Adrenergic blocking agents Adrenergic blocking agents

1980-08-22

1981-07-14

Niebling, John F.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

562430, C07C14390, C11D 128

Patent

active

042786088

ABSTRACT:
There are disclosed compounds of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of lower alkyl; R.sub.8 is selected from the group consisting of --O--(CH.sub.2).sub.n -- wherein n is 2 to 20, ##STR2## and ##STR3## and R.sub.6 is selected from the group consisting of hydrogen or lower alkoxy, and ##STR4## wherein R.sub.1 is selected from the group consisting of lower alkyl; R.sub.8 is selected from the group consisting of --O--(CH.sub.2).sub.n -- wherein n is 2 to 20, ##STR5## and ##STR6## and R.sub.6 is selected from the group consisting of hydrogen or lower alkoxy and racemates thereof.
There are also disclosed processes and intermediates utilized to produce the end products.
The end products have utility as agents exhibiting both .alpha. and selective .beta. adrenergic blocking action.

REFERENCES:
R. Howe et al., J. Med. Chem. 11, 1118 (1968).
B. Ablad et al., Acta. Pharmacol. Toxicol 25, 85 (1967).
L. Almirante et al., J. Med. Chem. 9, 650 (1966).
M. Dukes et al., J. Med. Chem. 14, 326 (1971).

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