Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1980-08-22
1981-08-25
Milestone, Norma S.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
26034858, C07D30346, C07D30338
Patent
active
042858739
ABSTRACT:
There are disclosed compounds of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of lower alkyl; R.sub.8 is selected from the group consisting of --O--(CH.sub.2).sub.n -- wherein n is 2 to 20, ##STR2## and R.sub.6 is selected from the group consisting of hydrogen or lower alkoxy, and ##STR3## wherein R.sub.1 is selected from the group consisting of lower alkyl; R.sub.8 is selected from the group consisting of --O--(CH.sub.2).sub.n -- wherein n is 2 to 20, ##EQU1## and R.sub.6 is selected from the group consisting of hydrogen or lower alkoxy and racemates thereof.
There are also disclosed processes and intermediates utilized to produce the end products.
The end products have utility as agents exhibiting both .alpha. and selective .beta. adrenergic blocking action.
REFERENCES:
patent: 3951983 (1976-04-01), Danilewicz et al.
Fahrenholtz Kenneth E.
Guthrie Robert W.
Kierstead Richard W.
Tilley Jefferson W.
Hoffman Frank P.
Hoffmann-La Roche Inc.
Leon Bernard S.
Milestone Norma S.
Saxe Jon S.
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