ADP-ribosyl transferase fusion proteins, pharmaceutical...

Details ADP-ribosyl transferase fusion proteins, pharmaceutical... ADP-ribosyl transferase fusion proteins, pharmaceutical...

2005-02-15

2005-02-15

Kemmerer, Elizabeth (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S300000, C530S350000

Reexamination Certificate

active

06855688

ABSTRACT:
The Rho family GTPases regulates axon growth and regeneration. Inactivation of Rho with C3, a toxin fromClostridium botulinum, can stimulate regeneration and sprouting of injured axons. The present invention provides novel chimeric C3-like Rho antagonists. These new antagonists are a significant improvement over C3 compounds because they are 3-4 orders of magnitude more potent to stimulate axon growth on inhibitory substrates than recombinant C3. The invention further provides evidence that these compounds promote repair when applied to the injured mammalian central nervous system.

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