ADP and ATP analogues, process for making and administration to

Details ADP and ATP analogues, process for making and administration to ADP and ATP analogues, process for making and administration to

1995-06-06

1997-08-05

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 48, 514 81, 536 2623, 536 2626, 544264, 544265, A61K 3170, C07H 1920, C07D47300

Patent

active

056542852

ABSTRACT:
There are disclosed compounds of formula I, ##STR1## wherein Q represents CR.sup.1 R.sup.2,
R represents O or CR.sup.3 R.sup.4,
W represents O or CH.sub.2,
R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen or halogen,
X represents S(O).sub.n R.sup.5, alkyl C.sub.1-6 alkoxy C.sub.1-6, acylamino C.sub.1-6, CONR.sup.6 R.sup.7, NR.sup.8 R.sup.9, halogen, a 5- or 6-membered S containing heterocycle, or phenyl optionally substituted by alkyl C.sub.1-6,
n represents 0, 1 or 2,
R.sup.5 represents aryl or alkyl C.sub.1-6 optionally substituted by one or more substituents selected from hydroxy, alkoxy C.sub.1-6, halogen and aryl;
R.sup.6, R.sup.7, R.sup.8 and R.sup.9 independently represent hydrogen or alkyl C.sub.1-6,
Y represents NH.sub.2 or alkoxy C.sub.1-6, and
Z represents an acidic moiety,
in addition, when R represents CR.sup.3 R.sup.4, then --Q--Z may also represent hydroxy or --OP(O)(OH).sub.2,
and pharmaceutically acceptable salts thereof, with certain provisos, for use as pharmaceuticals.

REFERENCES:
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