Adoptive immunotherapy using macrophages sensitized with heat sh

Details Adoptive immunotherapy using macrophages sensitized with heat sh Adoptive immunotherapy using macrophages sensitized with heat sh

1995-09-13

1999-11-16

Feisee, Lila

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

4241931, 4242771, 4241841, 424 857, 424 851, 424 852, 424 855, 424 856, 530350, 530351, 514 2, A01N 6300, A61K 39385, A61K 4505, C07K 14435

Patent

active

059852704

ABSTRACT:
The present invention relates to methods and compositions for enhancing immunological responses and for the prevention and treatment of infectious diseases or primary and metastatic neoplastic diseases based on the administration of macrophages and/or other antigen presenting cells (APC) sensitized with heat shock proteins non-covalently bound to peptide complexes and/or antigenic components. APC are incubated in the presence of hsp-peptide complexes and/or antigenic components in vitro. The sensitized cells are reinfused into the patient with or without treatment with cytokines including but not limited to interferon-.alpha., interferon-.alpha., interleukin-2, interleukin-4, interleukin-6 and tumor neurosis factor.

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