Administration system for estradiol

Details Administration system for estradiol Administration system for estradiol

1994-12-19

1997-09-09

Venkat, Jyothsan

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424449, A61F 1302

Patent

active

056653778

ABSTRACT:
The adhesive plaster for the transdermal administration of estradiol or mixture estradiol/progestin is composed of an impermeable carrier film and of an adhesive composition. The latter represents a matrix or reservoir layer and is composed of a solvent-based polyacrylate or polyisobutylene adhesive which contains a saturated or unsaturated fatty acid with 6 to 18 C atoms as permeability enhancer, estradiol or mixture estradiol/progestin as active substance and optionally propylene glycol as solvent.
The adhesive plaster is used for the systemic administration of hormones in hormone replacement therapy for a time of at least 3 days.

REFERENCES:
patent: 4390520 (1983-06-01), Nagai et al.
patent: 4816258 (1989-03-01), Nedberge et al.
patent: 4818540 (1989-04-01), Chien et al.
patent: 5023084 (1991-06-01), Chien et al.
patent: 5122382 (1992-06-01), Gale et al.
patent: 5145682 (1992-09-01), Chien et al.
patent: 5393529 (1995-02-01), Hoffmann et al.

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