Administration of valienamine-related disaccharide compounds in

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 53, 536 179, 536 187, 564462, A61K 3170, C07H 504

Patent

active

055717969

ABSTRACT:
The present invention is directed to methods of reducing the degree of inflammation arising from a secondary immune response in a mammal due to antigen exposure (challenge) by the administration of valienamine-related disaccharide compounds and the pharmaceutical compositions employed in the method.

REFERENCES:
patent: 4595678 (1986-06-01), Horii et al.
Ogawa et al.(I), "Synthesis of Adiposin-1, .alpha.-Glycoside Hydrolase Inhibitor," Chemistry Letters, (3), 337-340 (1983).
Asano et al.(I), "Microbial Degradation of Validamycin A by Flavobacterium Saccharophilum," J. Antibiotics, 37(8), 859-867 (1984).
Ogawa et al., (II), "Total Synthesis of (+)-Validamycin," J. Chem. Soc., Chem. Comm., (24), 1843-1844 (1987).
Yoshikawa et al., "Synthesis of Validamine, epi-Validamine, and Valienamine, Three Optically Active pseudo-Amino-Sugars, From D-Glucose," Chem. Pharm. Bull., 36 (10), 4236-4239 (1988).
Kameda et al.(I), "New Cyclitols, Degradation of Validamycin A by Flavobacterium Saccharophilum," J. Antibiotics, 33 (12), 1573-1574 (1980).
Kameda et al.(II), "Valienamine as an .alpha.-Glycosidase Inhibitor," J. Antibiotics, 33(12), 1575-1576 (1980).
Furumoto et al., "Enzymatic Synthesis of Valienamine Glycosides and Their Antibiotic Activity," J. Antibiotics, 44 (3), 371-373 (1991).
Asano et al.(II), "All Eight Possible Mono-.beta.-D-Glycosides of Validoxylamine A-I. Preparation and Structure Determination," J. Antibiotics, 44 (12), 1406-1416 (1991).
Asano et al.(III), "All Eight Possible Mono-.beta.-D-Glycosides of Validoxylamine A-II. Biological Activities," J. Antibiotics, 44 (12), 1417-1421 (1991).
Ogawa et al.(III), "Synthesis of Potent .alpha.-Glycosidase Inhibitors: Methyl Acarviosin Analogue Composed of 1,6-Anhydro-.beta.-D-glucopuranose Residue," J. Chem. Soc., Chem. Comm., (20), 1387-1388 (1990).
Ogawa et al.(IV), "Synthesis and Enzyme-Inhibitory Activity of Methyl Acarviosin Analogues Having the .alpha.-manno Configuration," Carbohydrate Research, 226, 79-89 (1992).
Ogawa et al.(V), "Chemical Modification of the Sugar Moiety of Methyl Acarviosin: Synthesis and Inhibitory Activity of Eight Analogues Containing a 1,6-Anhydro Bridge," Carbohydrate Research, 250 , 177-184 (1993).
Smith and Ziola, "Cyclophosphamide and dimethyl dioctadecyl ammonium bromide immunopotentiate the delayed-type hypersensitivity response to inactivated enveloped viruses", Immunology 58: 245-250 (1986).
Ogawa et al., "Synthetic Studies on Antibiotic Validamycins, Part 12. .sup.1,2 Total Synthesis of (+)-Validamycin B and (+)-Validoxylamine B", J. Chem. Soc. Perkin Trans 1:2675-2680 (1988).
Cerny et al., "Preparation of 2-Amino-1, 6-Anhydro-2-Deoxy-.beta.-D-Glucopyranose and 2-Amino-1,6 : 3,4-Dianhydro-2-Deoxy-.beta.-D-Galactopyranose", Collection Czechoslav. Chem. Commun.39:1391-1396 (1974).
Hayashida et al., "Novel Synthesis Of Penta-N, O-Acetylvaliolamine", J. Carbohydrate Chemistry, 7(1):83-94 (1988).
Ray and Matteson, "Osmium Tetroxide Catalyzed Hydroxylation of Hindered Olefins", Tetrahedron Lett. 21:499-450 (1980).
Kameda et al., "Valiolamine, a New .alpha.-Glucosidase Inhibiting Aminocyclitol Produced by Streptomyces Hygroscopicus", J. Antibio. 37:1301-1307 (1984).
Takeuchi et al., "Inhibitory Effect of Validamine, Valienamine and Valiolamine on Activities of Carbohydrases in Rat Small Intestinal Brush Border Membranes", Chem. Pharm. Bull 38(7):1970-1972 (1990).
Ogawa et al., "Synthetic Studies on the Validamycins 5..sup.1,2 Synthesis of DL-Hydroxyvalidamine and DL-Valienamine", J. Org. Chem. 48:1203-1207 (1983).
Paulsen et al., "Synthese von Pseudozuckern aus D-Glucose durch intramolekulare Horner-Emmons-Olefinierung", Liebigs Ann Chem. 125-131 (1987).
Kobayashi and Shiozaki, "Syntheses of Trehazolin Derivatives and Evaluation as Glycosidase Inhibitors", J. Org. Chem. 60:(8) 2570-2580 (1995).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Administration of valienamine-related disaccharide compounds in does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Administration of valienamine-related disaccharide compounds in , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Administration of valienamine-related disaccharide compounds in will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2015282

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.