Administration of thrombopoietin on a single day only

Details Administration of thrombopoietin on a single day only Administration of thrombopoietin on a single day only

1996-08-28

1999-03-09

Spector, Lorraine

Drug, bio-affecting and body treating compositions

Lymphokine

4241921, 4241931, 435 695, 435 697, 530351, 530402, A61K 3819

Patent

active

058796738

ABSTRACT:
The present invention is directed to the surprising and unexpected finding that biologically active thrombopoietin materials can be administered with substantial therapeutic effect at dosage rates commensurate with previously reported administration of such materials, but in a single or low-multiple daily administration. Thus, the predicate of the present invention relates to the reversal of thrombocytopenia by administering to a patient having or in need of such treatment a single or low-multiple daily dose of a therapeutically effective amount of a thrombopoietin. The preferable dose of the active material ranges from about 1 to about 10 .mu.g/kg body weight.

REFERENCES:
patent: 5578301 (1996-11-01), Myers
patent: 5593666 (1997-01-01), McDonald
patent: 5627267 (1997-05-01), Lyman
M.M. Hokom et al., Blood 86(12):4486-4492, Dec. 15 1995.
T.R. Ulich et al., Blood 86(3):971-976, Aug. 1 1995.
K. Kaushansky et al., J. Clin. Invest. 96:1683-1687, Sep. 1995.
Ulich et al., "The Prolonged Hematologic Effects of a Single Injection of PEG-rHuMGDF is Normal in Thrombocytopenic Mice," (Abstract No. 1399) Blood, 88:335a (1996). (Nov.).
Shibuya et al., "Single Injection of Pegylated Recombinant Human Megakaryocyte Growth and Development Factor (PEG-rHuMGDF) Promotes Hematologic Recovery in Irradiated Mice," (Abstract No. 1400) Blood, 88:335a (1996). (Nov.).

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