Administration of steroid hormones

Details Administration of steroid hormones Administration of steroid hormones

1987-09-09

1989-10-31

Sneed, H. M. S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 58, 514946, 514960, 514178, A61K 3170, A61K 3156

Patent

active

048777749

ABSTRACT:
Crystalline complexes of steroid hormones with gamma-cyclodextrin are prepared by mixing the components together. Tablets can be formed from the complexes, which can be administered by contact with the mucosa to provide effective transfer of the hormones into the systemic circulation, gradually eliminating the hormones therefrom.

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patent: 4727064 (1988-02-01), Pitha
Kempfle et al., "The Binding of Fluorescent Steroids to Cyclodextrins as Models for Steroid Protein Interaction", Chem. Abst. 106:113678, 1987.
Kempfle et al, "Fluorecent Steroids-Interactions with Cyclodextrins", Chem. Abst. 101:17560, 1984.
"Inclusion Complexations of Steroid Hormones with Cyclodextrins in Water and in Solid Phase", Uekama et al, Int. J. Pharm 10(1982): 1-15.

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