Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1984-04-25
1986-06-24
Love, Ethel G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
A61K 3170
Patent
active
045967954
ABSTRACT:
The administration of sex hormones, particularly testosteorne, progesterone and estradiol in the form of their complexes or inclusions with specific derivatives of cyclodextrins by the sublingual or buccal route results in effective transfer of these hormones into the systemic circulation, followed by only gradual elimination. To be effective in the above mode of administration, the derivatives of cyclodextrins must carry one or several substituents, each containing one or several hydroxy groups. Specially preferred are the following complexes: hydroxypropylbeta-cyclodextrin and poly-beta-cyclodextrin.
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patent: 4383992 (1983-05-01), Lipari
Fenyvesi et al. Water-Soluble Cyclodextrin Polymersing I. Int. Sympsoium on Cyclodextrins, p. 345 (Budapest, 1981).
Maeno, Liquid Crystal Element and Its Use, Chem. Abstracts 87 : 144000u (1977).
Kyowa Hakko Kogyo Co., Inclusion Compound of Medroxyprogesterone . . . and B-Cyclodextrin, Chem. Abstracts 98 : 8163z (1982).
Uekama et al., Inclusion Complexation of Steroid Hormones with Cyclodextrins . . ., Chem. Abstracts 96 : 149046j (1982).
Love Ethel G.
Roberts, Jr. John S.
The United States of America as represented by the Secretary, De
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