Administration of resveratrol to prevent or treat restenosis fol

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai

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514734, A01N 3108

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active

060229012

ABSTRACT:
A method for preventing or treating restenosis and for preventing the recurrence or progression of coronary heart disease is provided. The method involves administration of a selected active agent to a patient following coronary intervention, e.g., coronary artery bypass surgery, endarterectomy, heart transplantation, heart balloon angioplasty, atherectomy, laser ablation or endovascular stenting. The active agent comprises cis-resveratrol, trans-resveratrol, a mixture thereof, or a pharmacologically acceptable salt, ester, amide, prodrug or analog thereof. Administration may be oral, parenteral, or the like. Pharmaceutical compositions for use in conjunction with the therapeutic method are also provided.

REFERENCES:
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Tardif et al., "Probucol and Multivitamins in the Prevention of Restenosis After Coronary Angioplasty", The New Eng. J. Medicine 337:365-419, Aug. 1997.
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