Administration of pirenzepine, methyl scopolamine and other musc

Details Administration of pirenzepine, methyl scopolamine and other musc Administration of pirenzepine, methyl scopolamine and other musc

1995-06-01

1997-12-23

Weddington, Kevin E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514218, 514220, 514291, 514454, 514866, A61K 31545, A61K 3155, A61K 3144, A61K 3135

Patent

active

057007950

ABSTRACT:
Disclosed are methods for improving various aberrant metabolic indices in mammals including humans by administration of muscarinic (particularly M1) receptor antagonists alone or in combination with prolactin inhibiting compounds. Preferably the administration takes place at a predetermined time (or, if a combination of muscarinic receptor antagonist and prolactin inhibitor is used, at different predetermined times) during a 24-hour period when the administration is effective (or its effect more pronounced). The invention has application in the treatment of lipid and glucose metabolism disorders.

REFERENCES:
patent: 3074847 (1963-01-01), Bigsley
patent: 3752888 (1973-08-01), Fluckinger et al.
patent: 3755328 (1973-08-01), Stadler et al.
patent: 4219555 (1980-08-01), Rucman
patent: 4239763 (1980-12-01), Milavec
patent: 4659715 (1987-04-01), Meier
patent: 4749709 (1988-06-01), Meier
patent: 4783469 (1988-11-01), Meier
patent: 5006526 (1991-04-01), Meier
Harel et al., Proc. La. Acad. of Sci. 38:125, 1975.
Komorowski et al., Aliment. Nutr. Metab. 1(4):293, 1980.
Larsson et al., La Kartidningen (Sweden) 82(50):4425, 1985.
Martin et al., The Condor 75:369-374, 1973.
Martin et al., Chronobiology, "Hormonal Control of Orientation in the White-Throated Sparrow, Zonotrichia albicollis." pp. 641-646, 1974.
Martin et al., Proc. La. Acad. of Sci. 38:127, 1975.
Martin et al., Am. Zoologist 18(3):672, 1978.
Martin, D., "Hormonal Regulation of Migratory Orientation in the White-Throated Sparrow, Zonotrichia albicollis." Diss. LSU, 1974.
Martin, D., "Factors Influencing the Circadian Rhythm of Locomotor Activity in the Anabatoid Fish, Tirchogaster Trichopterus sumatramus." Thesis. Sam Houston State College, 1969.
Meier et al., Gen & Comp. Endocrinol. Supp 3:499-508, 1972.
Meier et al., Gen & Comp. Endocrinol. 26:253-258, 1975.
Meier et al., Physiol. Zool. 41(1):95-103, 1968.
Chemical Abstracts, vol. 118, No.21 issued 24 May 1993, Parkarinen et al., "Comparison of the effect of scopolamine and methylscopolamine on the performance of a fixed-ratio discrimination in squirrel monkeys" see p. 70, col. 1, abstract No. 205134y, Pharmacol., Biochem. Behav., 44(4), 815-19.
Atiea et al., J. Clin. Endocrinol 69: 390-5, 1989.
Barnett et al., Postgraduate Med. J. 56: 11-14, 1980.
Bell et al., Atherosclerosis 36: 47-54, 1980.
Bevan et al., Clinical Endocrinol. 36: 85-91, 1991.
Birdsall et al., Trends Pharmacol. Sci. 4: 459, 1983.
Blackburn, N.E.J.M. 309: 426-8, 1983.
Cincotta et al., Metabolism 40: 639-644, 1991.
Cincotta et al., Amer. J. Physiol. 264: E285-93, 1993.
Cincotta et al., Chronobiol. Int'l 10: 244-258, 1993.
Coiro et al., J. Endocrinol. Invest. 9: 27-30, 1986.
Coruzzi et al., Arch. Int. Pharmocodyn. Ther. 302: 232, 1989.
Coviezel et al., Acta Diabetol. Lat. (Italy) 26: 133-45, 1989.
Curtis-Prior et al., Experientia 35: 1430-1, 1979.
Davidson et al., Diabetes 37: 166-71, 1988.
Davidson et al., Diabetes Care 13: 813-4, 1990.
Davis et al., Psychoneuroendocrinology 7: 347-54, 1982.
El-Denshary et al., Life Sciences 40: 1531-5, 1987.
Fears, Biochem. Pharmacol. 33: 219-228, 1984.
Grigoriev et al., Aviat. and Environ. Med. 59: 301-5, 1988.
Harter et al., Dev. Endocrinol. 2: 331-49, 1978.
Haisenleder et al., Proc. Soc.. Exp. Biol. Med. 187: 341-9, 1988.
Illingworth & Conner in Endocrinology & Metabolism, Mc-Graw-Hill, New York, 1987.
Kawashima et al., Gen. Pharmacol. 21: 17, 1990.
Lambrecht et al., Trends Pharmacol Sci. 10 (Suppl): 60, 1989.
Martin et al., Neuroendocrinology 52: 9-14, 1990.
Martina et al., J. Clin Endocrinol. 68: 392-6, 1989.
Meier et al., Proc. Soc. Chronoendocrinol., in press.
Mendelson et al., J. Clin Invest. 61: 1683-90, 1978.
Negato et al., Comp. Biochem. Physiol. 106: 251-5, 1993.
Noma et al., Atherosclerosis 49: 1, 1983.
Ostinson et al., Endocrinol. 121: 1705-10, 1987.
Pietschmann et al., Acts Endocrinol. (Copenh) 117: 315-9, 1988.
Poland et al., Biol. Psychiatry 25: 403-12, 1989.
Risch et al., Psychoneuroendocrinology 11: 221-30, 1986.
Salans in Endocrinology & Metabolism, 2 ed., McGraw-Hill, New York 1987, pp. 1203-1244.
Stasiewicz et al., Acta Medica Hungarica 46: 189-95, 1989.
Thomas et al., Sem. Hop. Paris 53: 1857-62, 1977.
Thompson, Br. Heart J. 51: 585-8, 1989.
Williams, Textbook of Endocrinology, 1974, pp. 904-916.
Zaccoria et al., Eur. J. Clin. Pharmacol. 27: 701-5, 1985.
Bartness et al., J. Exp. Zoology 244: 437-454, 1987.
Berle, Acta Endocr. Suppl. 173, Abstract No. 104, 1973.
Burns, et al., Rev. Chronopharmacology 5:57-60, 1988.
Cincotta et al., J. Endocr. 103:141-146, 1984.
Cincotta et al., J. Endocr. 106:177-181, 1985.
Cincotta et al., J. Endocr. 106:173-176, 1985.
Cincotta et al., Experientia 43: 416-417, 1987.
Cincotta et al., Ann Nutr Metab 33:305-14, 1989.
Cincotta et al., Horm. Metabol. Res. 21:64-68, 1989.
Cincotta et al., J. Endocrinology 120:385-391, 1989.
Cincotta et al., Life Sciences 45:2247-2254, 1989.
Eisemann et al., J. of Animal Sci. 59(1)86-94, 1984.
Eisemann et al., J. of Animal Sci. 59(1)95-104, 1984.
Emata et al., J. Exp. Zoology 233:29-34, 1985.
Gnudi et al., Acta Diabetologica Latina 14:119-128, 1977.
Horseman et al., General and Comparative Endocrinology 38:269-274, 1979.
Horseman et al., J. Endocr. 82:367-372, 1979.
Iranmanesh et al., J. Clin. Endocrin & Metabo. 71: 73-7, 1990.
Joseph et al., J. Exp. Zool. 178(1):59-62, 1971.
Landgraf et al., Proc. German Med. Soc. 82nd Convention, Part II, Apr. 25-29, 1976.
Lee et al., J. of Exp. Zool. 166(3):307-316, 1967.
Lobato et al. Mol. and Cell. Biochem. 67:19-23, 1985.
Meier et al., Gen. & Comp. Endocrin. 8(1):110-114, 1967.
Meier, Gen. & Comp. Endocrin. Supp. 2:55-62, 1969.
Meier et al., Proc. Soc. Exp. Biol. and Med. 133 (4) :113-16, 1970.
Meier et al., Gen. & Comp. Endocrin. 17: 311-8, 1971.
Meier et al., Proc. Soc. for Exp. Bio. & Med. 137:408-415, 1971.
Meier et al., Science 173: 1240-42, 1971.
Meier et al., General and Comparative Endocrinology Suppl. 3:499-508, 1972.
Meier, Amer. Zoology, 15 : 905-916, 1975.
Meier et al., Amer. Zool. 16 : 649-659, 1976.
Meier et al., Amer. J. of Physiology 232(2) :E193-E196, 1977.
Meier et al., Compar. Endocrin. 141-44, 1978.
Meier et al., Current Ornithology 2 : 303-343, 1984.
Meier et al., Transactions of the American Fisheries Society 113: 422-431, 1984.
Meier et al., Experientia 48: 248-53, 1992.
Miller et al., J. Interdiscipl. Cycle Res. 14(1) : 75-84, 1983.
Miller et al., J. Interdiscipl. Cycle Res. 14(2) : 85-94, 1983.
Ottenweller et al., Life Science 28: 1033-1040, 1980.
Southern et al., J. Anim. Sci. 68:931-936, 1990.
Spieler et al., Gen. & Comparative Endocrinology 29:156-160, 1976.
Spieler et al., Life Sciences 22:255-258, 1997.
Wheeland, et al., Comp. Biochem. Physiol. 53B; 379-385, 1976.
Wilson et al., Chronobiology Int'l 6(2) :113-121, 1989.3:189-195, 1989.

Affiliated with

Also associated with

Rating

Administration of pirenzepine, methyl scopolamine and other musc does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Administration of pirenzepine, methyl scopolamine and other musc, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Administration of pirenzepine, methyl scopolamine and other musc will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1802878