Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-06-20
1997-09-16
Marquis, Melvyn I.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514271, 514288, 514291, 514824, A61K 31435, A61K 31495, C07D45100
Patent
active
056681550
ABSTRACT:
Disclosed are methods for improving various aberrant metabolic indices in mammals including humans by administration of muscarinic (particularly M1) receptor antagonists alone or in combination with prolactin inhibiting compounds. Preferably the administration takes place at a predetermined time (or, if a combination of muscarinic receptor antagonist and prolactin inhibitor is used, at different predetermined times) during a 24-hour period when the administration is effective (or its effect more pronounced). The invention has application in the treatment of lipid and glucose metabolism disorders.
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Kerr, D.J., et al., "Chronobiologic Quantification of Nocturnal Low-Dose Dopamine Effect on Circadian Rhythms of Thyroid-Related Hormones and Prolactin", Chronobiologia, 13(3), pp. 245-248. (1986).
Chemical Abstracts, vol. 118, No.21 issued 24 May 1993, Parkarinen et al., "Comparison of the effect of scopolamine and methylscopolamine on the performance of a fixed-ratio discrimination in squirrel monkeys" see page 70, col. 1, abstract no. 205134y, Pharmacol., Biochem. Behav., 44(4), 815-19.
Cincotta Anthony H.
Meier Albert H.
Wilson John M.
Harrison Robert H.
Marquis Melvyn I.
The Board of Supervisors of Louisiana State University and Agric
The General Hospital Corporation
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