Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-09-24
1989-03-28
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514297, 544361, 546105, A61K 3144, A61K 31495, C07D40100, C07D26536
Patent
active
048164569
ABSTRACT:
A method for treating central nervous system or peripheral nervous system cholinergic deficit states such as Alzheimer's disease in a mammal, said method comprising administering to said mammal an amount of a monoamine acridine derivative effective in the treatment of a cholinergic deficit state and for a time sufficient to achieve a suitable blood level to treat said cholinergic deficit state. The preferred monoamine acridine derivative is 1,2,3,4-tetrahydro-5-aminoacridine. A unit dosage pharmaceutical composition of matter comprising an effective amount of said monoamine acridine derivative sufficient to treat said cholinergic deficit state and a pharmaceutically acceptable inert carrier therefor is also disclosed.
REFERENCES:
patent: 1629873 (1927-05-01), Jensch
patent: 2083903 (1937-06-01), Hata et al.
patent: 3043842 (1962-07-01), Craig et al.
patent: 3489837 (1970-01-01), Hyman et al.
patent: 4631286 (1986-12-01), Shulstse et al.
Davis et al, "Selective Loss of Central Cholinergic Neurons in Alzheimer's Disease", Lancet (1980), vol. 2, p. 1403.
Harbaugh, M. D. et al, "Preliminary Report: Intracranial Cholinergic Drug Infusion in Patients with Alzheimer's Disease", Neurosurgery (1984), vol. 15, pp. 494-496.
Summers, W. K. et al, "THA--A Review of the Literature and Its Use in Treatment of Five Overdose Patients", Clinical Toxicology (1980), vol. 16, pp. 269-281.
Summers, W. K. et al, "Use of THA in Treatment of Alzheimer-Like Dementia: Pilot Study in Twelve Patients", Biological Psychiatry (1981), vol. 16, No. 2, pp. 145-153.
Kaye, W. H. et al, "Modest Facilitation of Memory in Dementia with Combined Lecithin and Anti-Cholinerestase (SR) Treatment", Biological Psychiatry (1982), vol. 17, No. 2, pp. 275-280.
Thal, L. J. et al, "Oral Physostigmine and Lecithin Improve Memory in Alzheimer's Disease", Annals of Neurology (1983), vol. 13, No. 5, pp. 491-496.
Soni, N. et al., "4-Aminopyridine--A Review", Anesthesia and Intensive Care (1982), vol. 10, pp. 120-126.
LandOfFree
Administration of monoamine acridines in cholinergic neuronal de does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Administration of monoamine acridines in cholinergic neuronal de, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Administration of monoamine acridines in cholinergic neuronal de will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1659376