Administration of low dose hemoglobin to increase perfusion

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530380, 530829, 424529, 424530, 424533, A61K 3514, A61K 3820

Patent

active

055104649

ABSTRACT:
This invention provides a method to therapeutically increase perfusion in a mammal comprising administering stroma-free hemoglobin at a dose ranging from the least amount effective to increase perfusion, up to a dose of about 2500 mg per kilogram of body weight.

REFERENCES:
patent: 4529719 (1985-07-01), Tye
patent: 5296466 (1994-03-01), Kilbourn et al.
patent: 5334706 (1994-08-01), Pezybeski
Parratt et al, Applied Cardiopulmonary Palmophysiology, vol. 4, pp. 143-149, 1991.
Kilbourn et al, Proc. Natl. Acad. Sci. USA, vol. 87, pp. 3629-3632, May 1990.
Kilbourn et al, Biochemical and Biophysical Research Communication, vol. 172, No. 3, pp. 1132-1138, Nov. 15, 1990.
Kosaka et al, Free Radical Biology & Medicine, vol. 7, pp. 653-658, 1989.
Buga et al, European Journal of Pharmacology, vol. 1612, pp. 61-72, 1989.
Martai et al, The Journal of Pharmacology and Experimental Therapeutics, vol. 232, No. 3, pp.-708-716, 1985.
G. P. Biro, et al, "Coronary Vascular Actions of Stroma-Free Hemoglobin Preparations", Artificial Organs, vol. 12, No. 1, 1988, pp. 40-50.
Robert F. Wilson, et al, "The use of arterial-central venous oxygen differences to calculate cardiac output and oxygen consumption in critically ill surgical patients", Surgery, vol. 84, No. 3, Sep. 1978, pp. 361-369.
S. A. Levinson, et al, "Effect of Exchange Transfusion with Fresh Whole Blood on Refractory Septic Shock" The American Surgeon, Jan. 1972, pp. 49-55.
C. J. Hauser, et al, "Hemoglobin solution in the treatment of hemorrhagic shock" Critical Care Medicine, vol. 10, No. 4, Apr. 1982, pp. 283-287.
John E. Nees, et al "Comparison of cardiorespiratory effects of crystalline hemoglobin, whole blood, albumin, and Ringer's lactate in the resucitation of hemorrhagic shock in dogs", Surgery, vol. 83, No. 6, jun. 1978, pp. 639-647.
William Martin, et al, "Selective Blockade of Endothelium-Dependant and Glyceral Trinitrate-Induced Relaxation by Hemoglobin and by Methylene Blue in the Rabbit Aorta", The Journal of Pharmacology and Experimental Therapeutics, vol. 232, No. 3, pp. 708-715.
Anne Bowman, et al, "Actions on the Cardiovascular System of an Inhibitory Material Extracted from the Bovine Retractor Penis", Br. J. Pharmac. (1981) 72, 365-372.
D. J. Stewart, et al, "The Role of Endothelium-derived Relaxing Factor (EDRF) in the Acetylcholine-induced Dilation of Coronary Resistance Vessels", Abstract No. 81 (1987).
U. Pohl, et al, "Endothelium-dependent modulation of vascular tone and platelet function" European Heart Journal (1990), 11, 35-42.
John S. Gillespie et al, "A comparison of haemoglobin and erythrocytes as inhibitors of smooth muscle relaxation by the NANC transmitter in the BRP and rat anococcygeus and by EDRF in the rabbit aortic strip", Br. J. Pharmacol, (1989), 98, 445-450.
U. Pohl, et al, "ERDF Increases Cyclic GMP in Platelets During passage Through the Coronary Vascular Bed", Circulation Research, vol. 65, No. 6, Dec. 1989.
Robert F. Furchgott, "Studies on Relaxation of Rabbit Aorta by Sodium Nitrite: The Basis for the Proposal that the Acid-Activatable Inhibitory Factor from Bovine Retrator Penis is Inorganic Nirite and the Endotheium-Derived Relaxing Factor is Nitric Oxide", Vasodilation: Vascular Smooth Muscle, Peptides, Autonomic Nerves, and Endothelium; 4th International Symposium on Mechanisms of Vasodilation, Rochester, Minnesota, Jul. 10-12, 1986, Raven press Ltd. New York, N.Y.
Ulrich Pohl, et al "EDRF-mediated shear-induced dilation opposes myogenic vasoconstriction in small rabbit arteries", Journal of Physiology, 261, (6):H2016-H2023 (1991).
Ulrich Pohl, et al "Hypoxia stimulates release of endothelium-derived relaxant factor", Am. J. Physiol. 256, 6 Part 2, 1989, H1595-H1600.
Carl A. Gruetter, et al, "Coronary Arterial Relaxation and Guanylate Cyclase Activation by Cigarette Smoke N'-Nitrosonornicotine and Nitric Oxide", J. of Pharmacology and Experimental Therapeutics, vol. 214, No. 1, pp. 9-15, 1980.
Peshin et al, Surgery, vol. 66, No. 1, pp. 185-193, Jul. 1969.
Savitsky et al, Clin. Pharmacol. Ther., vol. 23, No. 1, pp. 73-80, Jan. 1978.
Przyleski et al, J. Cab. Clin. med, vol. 17, No. 2, pp. 143-151, Feb. 1991.
Biro, G. P. et al., "The Effect of Hemodilution with Stroma-Free Hemoglobin and Dextran on Collateral Perfusion of Ischemic Myocardium in the Dog" Am. Hrt J, 99:64 (1980).
Buttle, G. A. R. et al., "Blood Substitutes in Treatment of Acute Hemorrhage" Lancet, 2:507 (1940).
Elia, C. et al., "Stroma-Free Hemolgobin in the Resuscitation of Hemorrhagic Shock" Surg Forum, 25:201 (1974).
Feola, M. et al., "Improved Oxygenationof Ischemic Myocardium by Hemodilution with Stroma-Free Hemoglobin Solution" Chest, 75:369 (1979).
Feola, M. et al., "Toxicity of Polymerized Hemoglobin Solutions" Surg. Gynecol Obstet, 166:211 (1988).
Jan, K. M. et al., "Coronary hemodynamics and Oxygen utilization after hematocrit Variations in Hemorrhage" Am. J. Physiol, 239:H326 (1980).
Jesch, F. H. et al., "Oxygen-Transporting Fluids and Oxygen Delivery with Hemodilution" Crit Care Med, 10:270 (1982).
Keipert, P. E. et al., "Pyridoxylated polyhemoglobin as a Red cEll Substitute for Resuscitation of Lethal Hemorrhagic Shock in Conscious Rats" Biomater Med Devices Artif Organs, 13:1 (1985).
Maningas , P. A. et al., "Hypertonic Sodium Chloride Solutions for the Prehospital Management of Traumatic Hemorrhagic Shock: A Possible Improvement in the Standard of Care?" Ann Emerg Med, 15:1411 (1986).
Miller, J. H. et al., "The Effect of Hemoglobin in Renal Function in the Human" J Clin Invest, 30:1033 (1951).
Moss, G. S. et al., "Transport of Oxygen and Carbon Dioxide by Hemoglobin-Saline Solution in the Red Cell Free Primate" Surg Gynecol Obstet, 142:357 (1976).
Prough, D. S. et al., "Effects of Hypertonic Saline Versus Lactated Ringer's Solution on Cerebral Oxygen Transport During Resuscitation from Hemorrhagic Shock"J Neurosurg, 64:627 (1986).
Rabiner, S. F. et al., J Exp med, 126:1127 to 1142 (1967).
Rabiner, S. F., "Hemoglobin Solution as a Plasma Expander" Fed Proc, 34:1454 (1975).
Shoemarker, W. C. et al., "Resuscitation of the Trauma Patient; Resotration of Hemodynamic Functions Using Clinical Algorithms" Ann Emerg Med, 15:1437 (1986).
Wade, C. E. et al., "Superiority of Hypertonic Saline/Dextran over Hypertonic Saline During the First 30 Minutes of Resuscitation Following Hemorrhagic Hyoptension in Concious Swine" Resuscitation, 20:49 (1990).
Relihan, M. et al., "Clearance Rate and Effect on Renal Function of Stroma-Free Hemoglobin Following Renal Ischemic" Ann Surg, 176:700 (1972).
Schmoker, J. D. et al., "Hypertonic Fluid Resuscitation Improves Cerebral Oxygen Delivery and reduces Intracarnial Pressure After Hemorrhagic Shock" J. Trauma 31:1607 (1991).
Shoemarker, W. C. et al., "Resuscitation of the Trauma Patient; Resotration of Hemodynamic Functions Using Clinical Algorithms" Ann Emerg Med, 15:1437 (1986).
Wade, C. E. et al., "Superiority of Hypertonic Saline/Dextran over Hypertonic Saline During the First 30 Minutes of Resuscitation Following Hemorrhagic Hyoptension in Conscious Swine" Resuscitation, 20:49 (1990).
Amberson, W. R. et al., "On Use of Ringer-Locke Solutions Containing Hemoglobin as a Substitute for Normal Blood in Mammals", J Cell Comp Physiol, 5:359 (1934).
Amberson, W. R. et al., "Clinical Experience with Hemoglobin-Saline Solutions" J Appl Physiol, 1:469 (1949).
Birndorf, N. I. et al., ":Effect of Red Cell stroma-Free Hemoglobin Solution on Renal Function in Monkeys" J Appl Physiol, 29:573 (1970).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Administration of low dose hemoglobin to increase perfusion does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Administration of low dose hemoglobin to increase perfusion, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Administration of low dose hemoglobin to increase perfusion will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2309480

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.