Administration of atipamezole to elicit a yohimbine-like alpha-a

Details Administration of atipamezole to elicit a yohimbine-like alpha-a Administration of atipamezole to elicit a yohimbine-like alpha-a

1995-03-16

1996-07-30

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31415

Patent

active

055412114

ABSTRACT:
The present invention is in the art of eliciting a yohimbine-like alpha-adrenoreceptor antagonistic noradrenergic neurotransmission male sexual activity response in penile erection. The improvement involves a more rapid onset of action and improved effect than that of yohimbine, consisting essentially of the step of administering the compound atipamezole or a pharmaceutically acceptable acid addition salt thereof to a male in need thereof. Atipamezole or pharmaceutically acceptable acid salt thereof may be administered perorally, intravenously, intramuscularly, transmucosally or transdermally.

REFERENCES:
patent: 4689339 (1987-08-01), Karjalainen et al.
"Atipamezole", Drugs Future, vol. 15, No. 5, 1990, pp. 448-452.
"Therapeutic Applications of Drugs Acting on Alpha-Adrenoceptors", E. MacDonald et al., Annals of Clinical Research, vol. 20, 1988, pp. 298-310.
"Increased Sexual Behavior in Male Macaca arctoides Monkeys Produced by Atipamezole, a Selective .beta.-.sub.2 -Adrenoceptor Antagonist", Ilkka Linnakoski et al., Pharmacology Biochemistry and Behavior, vol. 42, 1992, Pergamon Press Ltd.

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