Administration of anti-inflammatory drugs into the central...

Surgery: light – thermal – and electrical application – Light – thermal – and electrical application – Electrical therapeutic systems

Reexamination Certificate

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C604S020000, C604S514000

Reexamination Certificate

active

06853858

ABSTRACT:
Apparatus is provided for delivering a Non Steroidal Anti-Inflammatory Drug (NSAID) supplied to a body of a subject for delivery to at least a portion of a central nervous system (CNS) of the subject via a systemic blood circulation of the subject, including a stimulator adapted to stimulate at least one site of the subject, so as to cause an increase in passage of the NSAID from the systemic blood circulation across a blood brain barrier (BBB) of the subject to the portion of the CNS, during at least a portion of the time that the NSAID is present in the blood, the site selected from the list consisting of: a sphenopalatine ganglion (SPG) of the subject, an anterior ethmoidal nerve of the subject, a posterior ethmoidal nerve of the subject, a communicating branch between an anterior ethmoidal nerve and a retro-orbital branch of an SPG of the subject, a communicating branch between a posterior ethmoidal nerve and a retro-orbital branch of an SPG of the subject, a greater palatine nerve of the subject, a lesser palatine nerve of the subject, a sphenopalatine nerve of the subject, a communicating branch between a maxillary nerve and an SPG of the subject, a nasopalatine nerve of the subject, a posterior nasal nerve of the subject, an infraorbital nerve of the subject, an otic ganglion of the subject, an afferent fiber going into the otic ganglion of the subject, an efferent fiber going out of the otic ganglion of the subject, a vidian nerve of the subject, a greater superficial petrosal nerve of the subject, and a lesser deep petrosal nerve of the subject.

REFERENCES:
patent: 4152928 (1979-05-01), Roberts
patent: 4319580 (1982-03-01), Colley et al.
patent: 4886493 (1989-12-01), Yee
patent: 5031618 (1991-07-01), Mullett
patent: 5693077 (1997-12-01), Friedman
patent: 5855907 (1999-01-01), Peyman
patent: 5938690 (1999-08-01), Law et al.
patent: 6405079 (2002-06-01), Ansarinia
patent: 6432986 (2002-08-01), Levin
patent: 6491940 (2002-12-01), Levin
patent: 6526318 (2003-02-01), Ansarinia
patent: 6647980 (2003-11-01), Gizurarson
patent: 6678553 (2004-01-01), Lerner et al.
patent: 20010004644 (2001-06-01), Levin
patent: 20030133877 (2003-07-01), Levin
patent: WO 9903473 (1999-01-01), None
patent: WO 0044432 (2000-08-01), None
patent: WO 0143733 (2001-06-01), None
Branston NM, “The physiology of the cerebrovascular parasympathetic innervation,” British Journal of Neurosurgery 9:319-329 (1995).
Branston NM et al., “Contribution of cerebrovascular parasympathetic and sensory innervation to the short-term control of blood flow in rat cerebral cortex,” J Cereb Blood Flow Metab 15(3):525-31 (1995).
Toda N et al., “Cerebral vasodilation induced by stimulation of the pterygopalatine ganglion and greater petrosal nerve in anesthetized monkeys,” Neuroscience 96(2):393-398 (2000).
Seylaz J et al., “Effect of stimulation of the sphenopalatine ganglion on cortical blood flow in the rat,” J Cereb Blood Flow Metab 8(6):875-8 (1988).
Rucci L et al., “Histamine release from nasal mucosal mast cells in patients with chronic hypertrophic non-allergic rhinitis, after parasympathetic nerve stimulation,” Agents Actions 25(3-4):314-20 (1988).
L. Rucci, et al, “Effects of Vidian Nerve Stimulation on the Nasal and Maxillary Sinus Mucosa”, The Journal of Laryngology and Otology, Jun. 1984, vol. 98, pp. 597-607.
N. Toda, et al, “Preganglionic and Postganglionic Neurons Responsible for Cerebral Vasodilation Mediated by Nitric Oxide in Anesthetized Dogs”, J Cereb Blood Flow Metab. vol. 20 No. 4, 2000.
Ronald F. Young, “Electrical Stimulation of the Trigeminal nerve root for the Treatment of Chronic Facial Pain”, J Neurosurg 83:72-78, 1995.
L. Rucci, et al, “Vidian Nerve Resection in Chronic Hypertrophic Non Allergic Rhinitis: Effects on Histamine Content, Number and Rate of Degranulation Processes of Mast Cells in Nasal Mucosa”, Rhinology, 23, 309-314, 1985.
L. Rucci, et al, “Tympanometric Variations Induced by Vidian Nerve Stimulation in Humans”, The Journal of Laryngology and Otology, Apr. 1985, vol. 99, pp. 355-358.
E. Masini, et al, “Stimulation and Resection of Vidian Nerve in Patients with Chronic hypertrophic Non-Allergic Rhinitis: Effect on Histamine Content in Nasal Mucosa”, Agents and Actions, vol. 18, ½ 1986.
H. Bolay, et al, “Intrinsic Brain Activity Triggers Trigeminal Meningeal Afferents in a Migraine Model”, Feb. 2002, vol. 8 No. 2, pp. 136-142.
N. Suzuki, et al, “Origins and Pathways of Cerebrovascular Vasoactive Intestinal Polypeptide-Positive Nerves in Rat”, J Cereb Blood Flow Metab. vol. 8 No. 5, 1988.
Delephine, et al., “Plasma Protein Extravasation Induced in the Rat Dura Mater by Stimulation of the Parasympathetic Sphenopalatine Ganglion”, Experimental Neurology, 147, 389-400, 1997.
Hara H. Zhang, et al., “Parasympathetic Cerebrovascular Innervation: An Anterograde Tracing from the Sphenopalatine Ganglion in the Rat”, Neurosurgery, 32, 822-827, 1993.
G.L. Ruskell, “The Orbital Branches of the Pterygopalatine Ganglion and their Relationship with Internal Carotid Nerve Branches in Primates”, J. Anat. 1970, 106, 2, pp. 323-339.
Kroll RA, Neuwelt EA, “Outwitting the Blood Brain Barrier for Therapeutic Purposes: Osmotic Opening and Other Means”, Neurosurgery, 42, 1083-1100, 1998.
Sanders M, et al., “Efficacy of Sphenopalatine Ganglion Blockade in 66 Patients Suffering from Cluster Headache: A 12-70 Month Follow-Up Evaluation”, Journal of Neurosurgery, 87, 876-880, 1997.
Gloria Lee, et al, “Drug Transporters in the Central Nervous System: Brain Barriers and Brain Perenchyma Considerations”, Pharmacol Rev vol. 53, No. 4, pp. 569-596, 2001.
Van de WaterBeemd, et al., “Estimation of Blood Brain Barrier Crossing of Drugs Using Molecular Size and Shape and H bonding Descriptors”, Journal of Drug Targeting, 6, 151-165, 1998.
Suzuki, N. et al., “Selective Electrical Stimulation of postganglionic Cerebrovascular Parasympathetic Nerve Fibers Originating from the Sphenopalatine Ganglion Enhances Cortical Blood Flow in the Rat”, Journal of Cerebral Blood Flow and Metabolism, 10, 383-391 (1990).
Suzuki, N. et al., “Effect on Cortical Blood Flow of Electrical Stimulation of Trigeminal Cerebrovascular Nerve Fibers in the Rat”, Acta Physiol. Scand., 138, 307-315, 1990.
Samad TA et al., in an article entitled, “Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity,” in Nature 410(6827):471-5 (2001).
Major A, Silver W, “Odorants presented to the rat nasal cavity increase cortical blood flow,” Chem. Senses, 24, 665-669 (1999).
Fusco BM, Fiore G, Gallo F, Martilletti P, Giacovazzo M, “‘Capsaicin-sensitive’ sensory neurons in cluster headache: pathophysiological aspects and therapeutic indications,” Headache, 34, 132-137 (1994).
Lambert GA, Bogduk N, Goadsby PJ, Duckworth JW, Lance JW, “Decreased carotid arterial resistance in cats in response to trigeminal stimulation,” Journal of Neurosurgery, 61, 307-315 (1984).
Silver WL, “Neural and pharmacological basis for nasal irritation,” in Tucker WG, Leaderer BP, Molhave L, Cain WS (eds), Sources of Indoor Air Contaminants, Ann. NY Acad. Sci., 641, 152-163 (1992).

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