Administration of a 27-hydroxycholesterol or prodrug thereof as

Details Administration of a 27-hydroxycholesterol or prodrug thereof as Administration of a 27-hydroxycholesterol or prodrug thereof as

1997-04-04

1998-06-30

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514178, A61K 3156

Patent

active

057734313

ABSTRACT:
A method for preventing or reducing restenosis wherein a 27-hydroxycholesterol or a 25,26 and/or 27-aminocholesterol, or a sterol 27-hydroxylase stimulant, is administered in a restenosis preventing and/or reducing amount. The invention also includes a method for treating cancer using 27-hydroxycholesterol.

REFERENCES:
patent: 5587368 (1996-12-01), Javitt
Steroids, vol. 53, Nos. 3-5, issued 30 Mar. 1989, Parish et al., "Studies of the Oxysterol Inhibition of Tumor Cell Growth", pp. 579-596, Mar. 1989.
Ji, et al., Tetrahedron, vol. 46, pp. 487-502 (1990).

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