Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-10-28
2000-03-14
Moezie, Minna
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514415, A61K 31415, A61K 31405
Patent
active
060373601
ABSTRACT:
A method is provided for delaying the onset of ejaculation in an individual. The method involves administration of a 5-HT.sub.3 receptor antagonist within the context of an effective dosing regimen. The preferred mode of administration is transurethral; however, the selected inhibitor may also be delivered via intracavernosal injection or using alternative routes.
REFERENCES:
patent: 3717634 (1973-02-01), Wu et al.
patent: 4507323 (1985-03-01), Stern
patent: 4521421 (1985-06-01), Foreman
patent: 4766119 (1988-08-01), Davis
patent: 4828544 (1989-05-01), Lane et al.
patent: 4940731 (1990-07-01), Bick
patent: 5063915 (1991-11-01), Wyckoff
patent: 5151448 (1992-09-01), Crenshaw et al.
patent: 5242391 (1993-09-01), Place et al.
patent: 5248699 (1993-09-01), Sysko et al.
patent: 5276042 (1994-01-01), Crenshaw et al.
patent: 5327910 (1994-07-01), Flynn
patent: 5468212 (1995-11-01), Shooter
patent: 5474535 (1995-12-01), Place et al.
patent: 5476121 (1995-12-01), Place et al.
patent: 5482039 (1996-01-01), Place et al.
patent: 5535758 (1996-07-01), Hagihara
patent: 5552429 (1996-09-01), Wong et al.
patent: 5587167 (1996-12-01), Choi et al.
patent: 5597826 (1997-01-01), Howard et al.
patent: 5672612 (1997-09-01), Ronsen et al.
patent: 5707999 (1998-01-01), Cavallini
patent: 5922341 (1999-07-01), Smith et al.
Balon (1996) "Antidepressants in the Treatment of Premature Ejaculation," Journal of Sex & Marital Therapy 22(2):85-96.
Cavallini (1995,) "Alpha-1 Blockade Pharmacotherapy in Primitive Psychogenic Premature Ejaculation Resistant to Psychotherapy," Eur. Urology 28:126-130.
Di Silverio et al. (1996), "Effects Compares de l'Incision Cervico-Prostatique (ICP) et de l'Association ICP et Agonistes de la LHRH dans le Traitement de l'Hypertrophie Benigne de la Prostate," Journal D'Urologie 102(3):111-116.
Falaschi et al. (1981), "Brain Dopamine and Premature Ejaculation: Results of Treatment with Dopamine Antagonists," Apomorphine and Other Dopaminomimetics 1:117-121.
Feinberg (1991), "Clomipramine for Obsessive-Compulsive Disorder," AFP Clinical Pharmacology 43(5):1735-1738.
Ferrari et al (1994), "The Selective D.sub.2 Dopamine Receptor Antagonist Eticlopride Counteracts the Ejaculatio Praecox Induced by the Selective D.sub.2 Dopamine Agonist SND 919 in the Rat," Life Sciences 55(14):1155-1162.
Hull et al. (1994), "The Roles of Nitric Oxide in Sexual Function of Male Rats," Neuropharmacology 33(11):1499-1504.
Metz et al. (1997), "Premature Ejaculation: A Psychophysiological Review," Journal of Sex & Marital Therapy 23(1):3-23.
Napoli-Farris et al. (1984), "Stimulation of Dopamine Autoreceptors Elicits Premature Ejaculation in Rats," Pharmacology Biochemistry & Behavior 20:69-72.
Waldinger et al. (1997), "Ejaculation-Retarding Properties of Paroxetine in Patients with Primary Premature Ejaculation: A Double-Blind, Randomized, Dose-Response Study," British Journal of Urology 79:592-595.
WPIDS Abstract, AN 96-188218 [19], Nomura, K. et al., WO 9609069 A1, Mar. 28, 1996.
CA Abstract, AN 119:21000, Pomerantz, S. M. et al., 1993.
Pomerantz et al., Psychopharmacology, vol. 111, pp. 47-54, 1993.
Doherty, Jr. Paul C.
Place Virgil A.
Smith William L.
Hartrum J. Elin
Moezie Minna
Reed Dianne E.
Vivus Incorporated
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