Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Transferases
Reexamination Certificate
2005-07-26
2005-07-26
Naff, David M. (Department: 1651)
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Transferases
C424S094100, C514S002600, C514S009100, C435S177000, C530S402000, C530S812000
Reexamination Certificate
active
06921531
ABSTRACT:
Bifunctional molecules and methods for their use in the production of binary or tripartite complexes in a host are provided. The bifunctional molecule is a conjugate of a drug moiety and a presenter protein ligand. The molecular weight of the bifunctional molecule is less than about 5000 daltons. In the methods, an effective amount of the bifunctional molecule is administered to the host. In certain embodiments the bifunctional molecule binds to the presenter protein and a drug target to produce a tripartite complex, while in other embodiments the bifunctional molecule binds to either the presenter protein or the drug target, but not both, to produce a binary complex The subject methods and compositions find use in a variety of therapeutic applications.
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Briesewitz Roger
Crabtree Gerald R.
Ray Gregory Thomas
Vogel Kurt William
Wandless Thomas
Bozicevic Field & Francis LLP
Field Bret E.
Howard Hughes Medical Institute
Naff David M.
The Board of Trustees of the Leland Stanford Junior University
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