Adjuvants and methods for raising intracellular calcium ion conc

Details Adjuvants and methods for raising intracellular calcium ion conc Adjuvants and methods for raising intracellular calcium ion conc

1998-10-23

2000-11-21

Cook, Rebecca

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514537, A61K 3144

Patent

active

061504092

ABSTRACT:
Adjuvants for preventing adaptation to odors comprising one or compounds having the following formula (1): ##STR1## wherein R1 is a C1 to C8 lower alkyl group or a C7 to C9 aralkyl group, and R2 is a hydrogen atom or a C1 to C8 lower alkyl group, are described, as are compositions containing the same, and methods for preventing the adaptation to odors. Methods for increasing intracellular calcium ion levels and for prolonging the sensory response of chemoreceptive cells also described.

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Restrepo, D., et al., "Human olfactory neurons respond to odor stimuli with an increase in cytoplasmic Ca.sup.2+," Biophys. J.,1993, 64(6), 1961-1966.
Rawson, N.E., "Selectivity and response characteristics of human olfactory neurons", J. Neurosci., 1997, 1606-1613.
Schild, D., et al., "Transduction mechanisms in vertebrate olfactory receptor cells,"Physiol. Rev.,1998, 78(2), 429-466.
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