Adjuvant for pharmaceutical preparations

Details Adjuvant for pharmaceutical preparations Adjuvant for pharmaceutical preparations

1996-12-30

1998-12-29

Mullis, Jeffrey C.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From carbohydrate or derivative as a reactant

536115, 536119, 5361231, C08G 63668

Patent

active

058543686

ABSTRACT:
A polyester represented by the following general formula (I) and a copolymer which comprises two structural units represented by the following general formulae (I') and (II). ##STR1## and a coating material for use in large intestine-selective drug release pharmaceutical preparations, which contains the above polyester and/or copolymer. The polyester and copolymer of the present invention contain a saccharide residue which is hydrolyzed and/or assimilated specifically in the large intestine, drugs contained in solid oral pharmaceutical administration pharmaceutical preparations coated with the coating material of the present invention are not decomposed or absorbed by digestive organs other than the large intestine, but instead are released selectively and therefore in a high concentration in the large intestine.

REFERENCES:
patent: 2823188 (1958-01-01), Novak
patent: 3483169 (1969-12-01), Case et al.
patent: 3663463 (1972-05-01), Wren
patent: 3688763 (1972-09-01), Cromarty
patent: 3756966 (1973-09-01), Lamberti
patent: 3849341 (1974-11-01), Lamberti
patent: 3862121 (1975-01-01), Jaques et al.
patent: 4100342 (1978-07-01), Finley
patent: 4124571 (1978-11-01), Georgoudis
patent: 4151304 (1979-04-01), Evans et al.
patent: 4155884 (1979-05-01), Hughes
patent: 4713436 (1987-12-01), Downs et al.
patent: 5283064 (1994-02-01), Suzuki et al.
patent: 5294448 (1994-03-01), Ring et al.
patent: 5354559 (1994-10-01), Morehouse
patent: 5401512 (1995-03-01), Rhodes et al.
patent: 5444054 (1995-08-01), Garleb et al.
patent: 5525634 (1996-06-01), Sintov et al.
patent: 5576020 (1996-11-01), Iratani et al.
patent: 5644012 (1997-07-01), Iratani et al.
Journal of Polymer Science: Polymer Chemistry Edition, 18:365-370 (1980) International Search Report.
Saffran et al, "A New Approach to the Oral Administration of Insulin and Other Peptide Drugs", Science, 233:1081-1084 (Sep. 1986).
Kopecek et al, "Polymers for Colon-Specific Drug Delivery", J. Controlled Release, 19:121-130 (Feb. 1992).
Kurita et al, "Synthetic Polymers Containing Sugar Residues. V. Polyesters Derived from D-Cellobiose and Dicarboxylic Acid Chlorides by Direct Polycondensation", J. Polym. Sci.: Polym. Chem. Ed., 18:365-370 (Jan. 1980).
Lancaster et al, "Drug Delivery to the Colon: Polymer Susceptibility to Degradation by Colon Contents", Polymer Preprints, 30(1):480-481 (Apr. 1989).

Affiliated with

Also associated with

Rating

Adjuvant for pharmaceutical preparations does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Adjuvant for pharmaceutical preparations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Adjuvant for pharmaceutical preparations will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1425757