Chemistry: analytical and immunological testing – Involving producing or treating antigen or hapten – Producing labeled antigens
Patent
1985-04-04
1989-07-04
Kepplinger, Esther M.
Chemistry: analytical and immunological testing
Involving producing or treating antigen or hapten
Producing labeled antigens
435 5, 435 7, 424 86, 424 88, 424 89, 424 92, 424 858, 424 87, 424485, 514773, 514776, 514964, 514965, 436543, 436547, 436808, 427 3, G01N 33532, A61K 3939, A61K 3902, A61K 3912, A61K 39385
Patent
active
048450421
ABSTRACT:
The invention provides an immunizing agent or preparation e.g. a vaccine for parenteral administration comprising particles of coalesced and covalently interlinked physiologically compatible proteinaceous molecules and, entrapped in these particles, an immunogen adapted to be released by the gradual proteolysis of the particles and, when so released, being of sufficient size to elicit an immuno response to characteristic immunogenic determinants of the immunogen. The proteinaceous molecules are preferably homotypic for the animal to be immunized. Preferably, the particles or molecules carrying the immunogenic determinants are crosslinked to the proteinaceous molecules.
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Remy et al., The Lancet, vol. 2: 68-70 (1978).
Lee et al., Science, vol. 213: 233-235 (1981).
Hendry Donald A.
Newman John F. E.
Kepplinger Esther M.
South African Inventions Development Corporation
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