Adjuvant for immunization

Chemistry: analytical and immunological testing – Involving producing or treating antigen or hapten – Producing labeled antigens

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435 5, 435 7, 424 86, 424 88, 424 89, 424 92, 424 858, 424 87, 424485, 514773, 514776, 514964, 514965, 436543, 436547, 436808, 427 3, G01N 33532, A61K 3939, A61K 3902, A61K 3912, A61K 39385

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048450421

ABSTRACT:
The invention provides an immunizing agent or preparation e.g. a vaccine for parenteral administration comprising particles of coalesced and covalently interlinked physiologically compatible proteinaceous molecules and, entrapped in these particles, an immunogen adapted to be released by the gradual proteolysis of the particles and, when so released, being of sufficient size to elicit an immuno response to characteristic immunogenic determinants of the immunogen. The proteinaceous molecules are preferably homotypic for the animal to be immunized. Preferably, the particles or molecules carrying the immunogenic determinants are crosslinked to the proteinaceous molecules.

REFERENCES:
patent: 3937668 (1976-02-01), Zolle
patent: 4107288 (1978-08-01), Oppenheim et al.
patent: 4147767 (1979-04-01), Yapel, Jr.
patent: 4269821 (1981-05-01), Kreuter et al.
patent: 4357259 (1982-11-01), Senyei et al.
patent: 4367222 (1983-01-01), Kasper
patent: 4423034 (1983-12-01), Nakagawa et al.
patent: 4438208 (1984-03-01), Deftos
patent: 4585740 (1986-04-01), Vander Laan
Remy et al., The Lancet, vol. 2: 68-70 (1978).
Lee et al., Science, vol. 213: 233-235 (1981).

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