Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1995-06-07
1998-11-17
Achutamurthy, Ponnathapura
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
4241851, 4241941, 4242081, 4242111, 4242401, 4242191, 4242371, 4242561, 4242781, 436532, 530300, A61K 3900, A61K 3800, A61K 3100, C07K 1700
Patent
active
058372504
ABSTRACT:
Adjuvant compositions for modulating an immune response to an antigen administered to a host comprise a mineral salt adjuvant and at least one other adjuvant. The compositions provide an adjuvanting effect on an antigen which is greater than the adjuvanting effect attainable by one of the adjuvants alone. An antigen is covalently bonded to a glycolipid analog to provide a discrete molecule which exhibits an enhanced adjuvanting effect on the antigen which is greater than the adjuvanting effect attainable in the absence of such covalent bonding.
REFERENCES:
patent: 4057685 (1977-11-01), McIntire
patent: 4096245 (1978-06-01), Homma et al.
patent: 4258029 (1981-03-01), Moloney et al.
patent: 4596792 (1986-06-01), Vyas
patent: 4599230 (1986-07-01), Milich et al.
patent: 4599231 (1986-07-01), Milich et al.
patent: 4601903 (1986-07-01), Frasch
patent: 4737488 (1988-04-01), Lockhoff et al.
patent: 4762710 (1988-08-01), Sekura et al.
patent: 4855283 (1989-08-01), Lockhoff et al.
patent: 4891425 (1990-01-01), Lockhoff et al.
patent: 4997915 (1991-03-01), Tan et al.
patent: 5070190 (1991-12-01), Lockhoff et al.
patent: 5149650 (1992-09-01), Wertz et al.
Ramasamy et al. J. Natn. Sci. Coun. Sri Lanka, vol. 21, No. 1, 1993, pp. 125-140.
Nixon-George et al. (1990) J. Immunology 144:4798-4802.
Wiesmuller, (1989), Vaccine 8:29-33.
Deres et al, (1989), Nature 342:561.
Alving (1991) J. Immun. Methods 140:1-13.
Lockhoff (1991) Angew. Chem. Int. Ed. Engl. 30: 1611-1620.
Gupta, et al, (1993) Vaccine 11: 293-306.
Richards et al, (1988) Inf. and Immun. 56:682-686.
Vanlandschoot et al, (1993) Vaccine 12: 1185-1187.
Stunkel et al, (1989) Prog. Leukocyte Biol. 9:575-579.
Durette et al. "Synthesis and Immunoadjuvant Activity of 2-acet-amido-1,5-anhydro . . . " Carbohydrate Research 108(1982) 139-147.
Stunkel et al. "Synthesis Glycolipids with Immunopotentiating Activity on Humoral Immunity: Evaluation in vivo" Prog. Leukocyte Biol 9( Cell. Basis Immune Modulation) (1989) 575-579.
Chong Pele
James Olive A.
Kandil Ali
Klein Michel H.
Achutamurthy Ponnathapura
Bui Phuong T.
Connaught Laboratories Limited
LandOfFree
Adjuvant compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Adjuvant compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Adjuvant compositions will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-881440