Adjuvant complexes and vaccine made therefrom

Details Adjuvant complexes and vaccine made therefrom Adjuvant complexes and vaccine made therefrom

1990-12-07

1993-01-12

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Lymphokine

424 89, 424 92, 530403, 530405, 530406, A61K 3900

Patent

active

051788608

ABSTRACT:
"Iscom" adjuvant matrices, comprising a sterol, a glycoside, a solubilized water-insoluble antigen and, optionally, a phospholipid, may be formed without removing the solubilizing agent used for the antigen.
The glycoside is preferably Quil A and the sterol is preferably cholesterol.

REFERENCES:
patent: 4981684 (1991-01-01), MacKenzie
Trudel et al., (1987) Vaccine 5, 239-243.
Chemical Abstracts, vol. 107, No. 24, Dec. 14, 1987, p. 354, Abstract No. 223109w, Columbus, Ohio, U.S., M. Trudel, et al., "Vaccination of Rabbits with a Bovine Herpesvirus Type 1 Subunit Vaccine: Adjuvant Effect of ISCOMS".

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