Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Reexamination Certificate
2004-09-27
2008-11-25
Devi, S. (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
C424S257100, C424S234100, C424S190100, C424S282100, C424S201100, C424S203100, C424S202100, C424S192100, C424S193100, C514S002600
Reexamination Certificate
active
07455843
ABSTRACT:
The present invention describes the adjuvant activity of mutants of LT-IIa and LT-IIb enterotoxin which lack ganglioside binding activity. The adjuvant activity of the LT-IIb(T13I) mutant is comparable to that of the wild type LT-IIb. The adjuvant activity of LT-IIa(T34I) mutant is also described which exhibits a late onset adjuvant activity. These mutants are useful for enhancing immune response to antigens.
REFERENCES:
patent: 2002/0004238 (2002-01-01), Russell et al.
patent: WO- 01/27144 (2001-04-01), None
Nawar et al. Infect. Immun. 73: 1330-1342, Mar. 2005.
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Martin, et al.,Distinct Cytokine Regulation by Cholera Toxin and Type II Heat-Labile Toxins Involves Differential Regulation of CD40 Ligand on CD4+T Cells, Infection and Immunity, Jul. 2001, vol. 69 No. 7, pp. 4486-4492.
Martin, et al.,Comparative Analysis of the Mucosal Adjuvanticity of the Type II Heat-Labile Enterotoxins LT-IIa and LT-IIb, Infection and Immunity, Jan. 2000, vol. 68, NO. 1, pp. 281-287.
Connell, et al.,Immunostimulatory activity of LT-II a, a type II heat-labile enterotoxin of Escherichia coli, Elsevier Immunology Letters 62 (1998) pp. 117-120.
Martin, Michael,Immunomodulatory Effects of Type I and Type II Heat-Labile Enterotoxins on Mucosal and Systemic Immunity, Dissertation, (2000), Birmingham, Alabama.
Connell, et al.,Mutational analysis of the ganglioside-binding activity of the type II Escherichia coli heat-labile enterotoxin LT-IIb, Molecular Microbiology, 1995, 16(1): 21-31.
Pickett, et al.,Genetics of Type IIa Heat-Labile Enterotoxin of Escherichia coli: Operon Fusions, Nucleotide Sequence, and Hybridization Studies, Journal of Bacteriology, Nov. 1987: 5180-5187.
Arce Sergio
Connell Terry D.
Nawar Hesham
Russell Michael W.
Devi S.
Hodgson & Russ LLP
Research Foundation of State University of New York, The
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