Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-12-17
1993-12-21
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514318, A61K 31435, A61K 31445
Patent
active
052721590
ABSTRACT:
Various cyproheptadine derivatives sensitize multidrug resistant cells to certain chemotherapeutic agents. As such, these cyproheptadine derivatives are useful as adjuncts in the reversal of multidrug resistance in mammalian tumor cells either as compounds, pharmaceutically acceptable salts, or pharmaceutical composition ingredients in combination with anticancer chemotherapeutic agents or compounds.
REFERENCES:
Wu et al, "Multi-drug-Resistant Phenotype of Disease Oriented Panels of Human Tumor Cell Lines" Cancer Res. 52(11) 3029-3034 (1992).
Baldwin John J.
Remy David C.
Ayler Sylvia A.
Chang Celia
Daniel Mark R.
DiPrima Joseph F.
Ivy C. Warren
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