Adjacently substituted cycloalkane-amide analgesics

Details Adjacently substituted cycloalkane-amide analgesics Adjacently substituted cycloalkane-amide analgesics

1981-04-09

1982-11-16

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

548407, 549 39, 549333, 2603303, 546 15, 546230, 546231, 546234, 424244, 424267, 424275, 424278, 424304, 424309, 424311, 424324, 564155, 564162, 564163, 564166, 560 16, 560251, C07D48700, A61K 3140

Patent

active

043594760

ABSTRACT:
N-[2-Amino(oxy or thio group) substituted-cycloaliphatic]phenylacetamide and -benzamide compounds, having the oxy- or thio group substituents on a cycloaliphatic ring carbon adjacent to either of the nitrogen bearing carbons of the cycloaliphatic ring, e.g., cis- and trans-4-bromo-N-[3-methoxy-2-(1-pyrrolidinyl)cyclohexyl]-N-methylbenzamide , and trans-3,4-dichloro-N-methyl-N-[7-(1-pyrridolinyl)-1,4-dioxaspiro[4.5]dec-6 -yl]benzeneacetamide, and salts thereof, have useful analgesic activity and low abuse liability in humans and valuable warm blooded animals. Processes for their production and pharmaceutical compositions and method of use are also disclosed.

REFERENCES:
patent: 3510492 (1970-05-01), Szmuszkovicz
patent: 4065573 (1977-12-01), Lednicer
patent: 4098904 (1978-07-01), Szmuskovicz
patent: 4145435 (1979-03-01), Szmuszkovicz
patent: 4156733 (1979-05-01), Szmuszkovicz
patent: 4212878 (1980-07-01), Lednicer et al.

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