Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2006-07-18
2006-07-18
Kemmerer, Elizabeth (Department: 1647)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C435S375000, C435S383000
Reexamination Certificate
active
07078230
ABSTRACT:
The invention is in the area of pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof. In particular, the invention includes isolated adipose tissue derived stromal cells that have been induced to express at least one phenotypic characteristic of a neuronal, astroglial, hematopoietic progenitor, or hepatic cell. The invention also includes an isolated adipocyte tissue-derived stromal cell that has been dedifferentiated such that there is an absence of adipocyte phenotypic markers.
REFERENCES:
patent: 5041138 (1991-08-01), Vacanti et al.
patent: 5144016 (1992-09-01), Skjak-Braek et al.
patent: 5486359 (1996-01-01), Caplan et al.
patent: 5516532 (1996-05-01), Atala et al.
patent: 5536656 (1996-07-01), Kemp et al.
patent: 5709854 (1998-01-01), Griffith-Cima et al.
patent: 5723331 (1998-03-01), Tubo et al.
patent: 5736372 (1998-04-01), Vacanti et al.
patent: 5736396 (1998-04-01), Bruder et al.
patent: 5741685 (1998-04-01), Vacanti
patent: 5759830 (1998-06-01), Vacanti et al.
patent: 5770193 (1998-06-01), Vacanti et al.
patent: 5770417 (1998-06-01), Vacanti et al.
patent: 5786207 (1998-07-01), Katz et al.
patent: 5804178 (1998-09-01), Vacanti et al.
patent: 5811094 (1998-09-01), Caplan et al.
patent: 5827735 (1998-10-01), Young et al.
patent: 5855610 (1999-01-01), Vacanti et al.
patent: 5863531 (1999-01-01), Naughton et al.
patent: 5879940 (1999-03-01), Torok-Storb et al.
patent: 5902741 (1999-05-01), Purchio et al.
patent: 5908784 (1999-06-01), Johnstone et al.
patent: 5942225 (1999-08-01), Bruder et al.
patent: 5944754 (1999-08-01), Vacanti
patent: 6027744 (2000-02-01), Vacanti et al.
patent: 6030836 (2000-02-01), Thiede et al.
patent: 6103522 (2000-08-01), Torok-Storb et al.
patent: 6123727 (2000-09-01), Vacanti et al.
patent: 6139574 (2000-10-01), Vacanti et al.
patent: 6143501 (2000-11-01), Sittinger et al.
patent: 6153432 (2000-11-01), Halvorsen et al.
patent: 6200606 (2001-03-01), Peterson et al.
patent: 6391297 (2002-05-01), Halvorsen
patent: 6429013 (2002-08-01), Halvorsen et al.
patent: WO 96/02662 (1996-02-01), None
patent: WO 98/20731 (1998-05-01), None
patent: WO 99/28444 (1999-06-01), None
patent: WO 99/43286 (1999-09-01), None
patent: WO 99/61587 (1999-12-01), None
patent: WO 00/44882 (2000-08-01), None
patent: WO 00/53795 (2000-09-01), None
patent: WO 01/21767 (2001-03-01), None
Kim et al. Effect of partial hepatectomy on in vivo engraftment after intravenous administration of human adipose tissue stroma cells in mouse. Microsurgery 23:424-431, 2003.
Halliday et al. Alzheimer's disease and inflammation: a review of cellular and therapeutic mechanisms. Clin Exp Pharmacol Physiol 27: 1-8, 2000.
Feigin et al. Recent advances in Huntington's disease: implication for experimental therapeutics. Curr Opin Neurol 15: 483-489. 2002.
Steece-Collier et al. Etiology of Parkinson's disease: genetics and environment revisited. Proc Natl Acad Sci USA 99(22): 13972-13974, 2002.
Yang et al. Adipose tissue-derived stromal cells express neuronal phenotypes. Chin Med J 116(3): 425-429, 2004.
Safford et al. Characterization of neuronal/glial differentiation of murine adipose-derived adult stromal cells. Exp Neurol 187: 319-328, 2004.
Kang et al. Neurogenesis of rhesus adipose stromal cells. J Cell Sci 117: 4289-4299, 2004.
Kang et al. Improvement of neurological deficits by intracerebral transplantation of human adipose tissue-derived stromal cells after cerebral ischemia in rats. Exp Neurol 183: 355-366, 2003.
Erikson, G et al. Chondrogenic Potential of Adipose Tissue-Derived Stromal Cells in Vitro and in Vivo. Biochem Biophys Res Comm 290(2): 763-769, 2002.
Halvorsen et al. Thiazolidinediones and glucocorticoids synergistically induce differentiation of human adipose tissue stromal cells: biochemical, cellular, and molecular analysis. Metabolism. 50(4):407-413, 2001.
Halvorsen et al. Adipose-derived stromal cells—their utility and potential in bone formation. Int J Obes Relat Metab Disord. Suppl 4:S41-44, 2000.
Halvorsen et al. Extracellular matrix mineralization and osteoblast gene expression by human adipose tissue-derived stromal cells. Tissue Eng. 7(6):729-741, 2001.
Zuk Pa et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell. 13(12):4279-4295, 2002.
Safford et al. Neurogenic differentiation of murine and human adipose-derived stromal cells. Biochem Biophys Res Commun. 294(2):371-379, 2002.
Sen A et al. Adipogenic potential of human adipose derived stromal cells from multiple donors is heterogeneous. J Cell Biochem. 81(2):312-319, 2001.
Burris et al.,A Novel Method for Analysis of Nuclear Receptor Function at Natural Promoters: Peroxisome Proliferator-Activated Receptor γ Agonist Actions on a P2 Gene Expression Detected Using Branched DNA Messenger RNA Quantitation,Molecular Endocrinology, 1999, 13, 3, 410.
Gimble, Jeffrey Martin,The Function of Adipocytes in the Bone Marrow Stroma,The New Biologist, 1990, 2, 4, 304.
Gimble et al.,Nuclear Hormone Receptors and Adipogenesis,Critical Reviews in Eukaryotic Gene Expression, 1998, 8(2), 141.
Gimble et al.,Adipocyte Biology of the Bone,Adipocyte Biology and Hormone Signaling, IOS Press, The Netherlands, 2000, 231.
Gronthos et al.,Surface Protein Characterization of Human Adipose Tissue-Derived Stromal Cells,Journal of Cellular Physiology, 2001, 9999, 1.
Mizuno, M.D., Hiroshi,The Myogenic Potential of Human Processed Lipoaspirates—Part I: Morphological, immunohistochemical analysis and gene expression,J. Jpn.P.R.S., 2001, 21, 427.
Mizuno et al.,Myogenic Differentiation by Human Processed Lipoaspirate Cells,Plastic and Reconstructive Surgery2002, 109, 1, 199.
Saladin et al.,Differential Regulation of Peroxisome Proliferator Activated Receptor γ1(PPARγ1)and PPARγ2 Messenger RNA Expression in the Early Stages of Adipogenesis1,Cell Growth&Differentiation, 1999, 10, 43.
Zuk et al.,Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies,Tissue Engineering, 2001, 7, 2, 211.
Bain et al., “Embryonic Stem Cells Express neuronal Properties in Vitro,”Develop. Biol., 168:342-357.
Beresford et al., “Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stormal cell cultures,”J. Cell Sci., (1992), 99:131.
Bjornson, “Turning Brain into Blood: A Hematopoietic Fate Adopted by Adult Neural Stem Cells in Vivo,”Science, (1999), 283:534-537.
Bruder et al., “Mesenchymal Stem Cells in Bone Development, Bone Repair, and Skeletal Regeneration Therapy,”J. Cell Biochem., (1994), 56:283-294.
Dani et al., “Differentiation of embryonic stem cells into adipocytes in vitro,” J.Cell Sci., (1997) 110:1279-1285.
Dorheim et al., “Osteoblastic Gene Expression During Adiopogensis in Hematopoietic Supporting Murine Bone Marrow Stromal Cells,”J. Cell. Physiol., (1993), 154:317-328.
Gimble et al., “Adipogensis in a murine bone marrow stromal cell line capable of supporting B lineage lymphocyte growth and proliferation: biochemical and molecular characterization,”Eur. J. Immunol., (1990), 20:379-387.
Gimble et al., “Characterization of Murine Bone Marrow and Spleen-Derived Stromal Cells: Analysis of Leukocyte Marker and Growth Factor mRNA transcript Levels,”Blood, (1989) 74:303-311.
Gimble et al., “The Function of Adipocytes in the Bone Marrow Stromal: An Update,”Bone, (1996), 19:421-428.
Gronthos et al., “The STRO-1+ Fraction of Adult Human Bone Marrow Contains the Osteogenic Precursors,”Blood, (1994), 84:4164-4173.
Jakoby & Pastan, “Basic Methods” and “Media and Growth Requirements,”Methods in Enzymology,Cell Culture, vol. LVIII, pp. 62-72.
Jackson et al., “Hematopoietic potential of stem cells isolated from murine skeletal muscle,”PNAS, (1999), 96:14482-14486.
Johnson RS, “Targeting of Nonexpressed Genes in Embyronic Stem Cells Via Homologous Recombination,”Science, (1989), 245:1234-1
Gimble Jeffrey
Wilkison William O.
Artecel, Inc.
Bunner Bridget E.
Drinker Biddle & Reath LLP
Kemmerer Elizabeth
LandOfFree
Adipose tissue-derived stromal cell that expresses... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Adipose tissue-derived stromal cell that expresses..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Adipose tissue-derived stromal cell that expresses... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3529182