Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-09-14
1995-08-29
Schwartz, Richard A.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 691, 4351723, C12N 1511, C12N 1509
Patent
active
054461430
ABSTRACT:
The present invention relates generally to the control and regulation of estrogen biosynthesis. Estrogen biosynthesis is catalyzed by a microsomal enzyme, aromatase cytochrome P450 (P450arom; the product of the CYP19 gene). Tissue-specific expression of P450arom is determined by the use of tissue-specific promoters which give rise to P450arom transcripts with unique 5' noncoding sequences. Two unique 5'-untranslated exons of the CYP19 gene, I.3 and I.4., which are present in adipose tissue and adipose stromal cells (ASC) in culture have been identified. I.3-specific sequence is expressed in adipose tissue as well as in ACS maintained under all culture conditions, I.4-specific sequence is apparently present only in breast adipose tissue, and ACS stimulated with gluocorticoids.
REFERENCES:
Harada et al., "Structural Characterization of the Human Estrogen Synthetase (Aromatase) Gene," Biochemical and Biophysical Research Communications, 166(1):365-372, 1990.
Kilgore et al., "Alternative Promotion of Aromatase P-450 Expression in the Human Placenta," Molecular and Cellular Endocrinology, 83:R9-R16, 1992.
Mahendroo et al., "Tissue--specific Expression of Human P-450," The Journal of Biological Chemistry, 266(17):11276-11281, 1991.
Mahendroo et al., "Tissue--Specific and Hormonally--Controlled Alternative Promoters Regulate Aromatase Cytochrome P450 Gene Expression in Human Adipose Tissue," Journal of Biological Chemistry, 268(26):19463-19470, 1993.
Means et al., "Tissue--Specific Promoters Regulate Aromatase Cytochrome P450 Gene Expression in Human Ovary and Fetal Tissues," Molecular Endocrinology, 5(12):2005-2013, 1991.
Means et al., "Structural Analysis of the Gene Encoding Human Aromatase Cytochrome P-450, the Enzyme Responsible for Estrogen Biosynthesis," The Journal of Biological Chemistry, 264(32):19385-19391, 1989.
Simpson et al., "Regulation of Human Aromatase Cytochrome P450 Gene Expression," J. Steroid Biochem. Molec. Biol., 43(8):923-930, 1992.
Simpson et al., "Regulation of Expression of the Genes Encoding Steroidogenic Enzymes," J. Steriod Biochem. Molec. Biol., 40(1-3), 1991.
Simpson et al., "Tissue--Specific Promoters Regulate Aromatase Cytochrome P450 Expression," Clinical Chemistry, 39(2):317-324, 1993.
Toda et al., "Characterization of a cis--acting regulatory element involved in human--aromatase P-450 gene expression," Eur. J. Biochem., 205:303-309, 1992.
Toda et al., "Structural and functional characterization of human aromatase P-405 gene," Eur. J. Biochem., 193:559-565, 1990.
Wang and Chen, "Identification of a Promoter and a Silencer at the 3'--End of the First Intron of the Human Aromatase Gene," Molecular Endocrinology, 6(9):1479-1488, 1992.
Zhou et al., "Stable Expression of Human Aromatase Complementary DNA in Mammalian Cells: A Useful System for Aromatase Inhibitor Screening," Cancer Research, 50:6949-6954, 1990.
Mahendroo Mala S.
Mendelson Carole R.
Simpson Evan R.
Board of Regents , The University of Texas System
Schwartz Richard A.
Vogel Nancy T.
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