Adipocyte complement related protein zacrp13

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C530S300000, C530S356000, C514S012200

Reexamination Certificate

active

06955899

ABSTRACT:
The present invention relates to polynucleotide and polypeptide molecules for zacrp13, a novel member of the family of proteins bearing a collagen-like domain and a C1q domain. Novel zacrp13 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. Also disclosed are antibodies to the zacrp13 protein or fragments thereof.

REFERENCES:
patent: WO 00/63376 (2000-10-01), None
patent: WO 00/63377 (2000-10-01), None
patent: WO 02/55694 (2002-07-01), None
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, GenBank Locus TMSHP20A, Accession No. D12974, “Tamias asiaticus mRNA for HP-20, complete cds,” [online], Bethesda, MD [retrieved on Dec. 3, 2002]. Retrieved from the Internet:<http://www.ncbi.nlm.nih.gov/entrez/query.fegi?cmd=Retrieve&db=nucleotide&list_uids=287467&dopt=GenBank>, 2 pages.
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, GenBank Locus A48150, Accession No. A48150, “Hibernation-related protein HP-20 precursor—Siberian chipmunk,” [online], Bethesda, MD [retrieved on Dec. 3, 2002]. Retrieved from the Internet:<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=nucleotide&list_uids=2302012&dopt=GenBank>, 2 pages.
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, GenBank Locus Q06575, Accession No. Q06575, “Hibernation-associated plasma protein HP-20 precursor (Hiberntor-specific blood complex, 20 kDa subunit),” [online], Bethesda, MD [retrieved on Dec. 3, 2002]. Retrieved from the Internet:<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=protein&list_uids=1170339&dopt=GenPept>, 2 pages.
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, GenBank Locus AK024120, Accession No. AK024120, “Homo sapienscDNA FLJ14058 fis, clone HEMBB1000554,” [online], Bethesda, MD [retrieved on Dec. 3, 2002]. Retrieved from the Internet:<http://www.ncbi.nlm.nih.gov/entrez/query.fegi?cmd=Retrieve&db=nucleotide&list_uids=10436423&dopt=GenBank>, 2 pages.
Scherer et al., “A Novel Serum Protein Similar to C1q. Produced Exclusively in Adipocytes,” J Biol Chem. Nov. 10, 1995;270(45):26746-9.
Sellar et al., “Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C1q. The complete derived acid amino acid sequence of human C1q,” Biochem J. Mar. 1, 1991;274 (Pt 2):481-90.
Shapiro et al., “The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor,”Curr Biol. Mar. 12, 1998;8(6):335-8.
Bridgeman, A., “Human DNA sequence from clone RP1-302D9 on chromosome 22, complete sequence,” GenBank Accession No. Z82198, version Z82198.2, submitted Dec. 8, 1999.
Maeda et al., “cDNA Cloning and Expression of a Novel Adipose Specific Collagen-like Factor, apM1 (Adipose Most Abundant Gene Transcript 1).”Biochem Biophys Res Comm 221(2):286-9, Apr. 16, 1996.
Accession No. Z82198. Human DNA sequence from clone RP1-302D9 on chromosome 22 Contains GSSs, complete sequence.
Lee, J, Choi Sl, Jang JS, Jang K, Moon JW, Bae CS, Yang DS, Seong BL, “Novel secretion system of recombinantSaccharomyces cerevisiaeusing an N-terminus residue of human IL-1 beta as secretion enhancer,” Biotechnol Prog. 15(5):884-90, 1999.

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