Adhesives resistant to skin-penetration enhancers

Details Adhesives resistant to skin-penetration enhancers Adhesives resistant to skin-penetration enhancers

1997-08-25

1999-06-29

Buttner, David

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

525 5423, 525 5426, 525183, 525187, 525217, 527314, 424448, 424449, C09J10500, C09J13308

Patent

active

059169680

ABSTRACT:
A graft copolymer for use as an adhesive for drug delivery patches or dressings that is resistant to dissolution in the presence of skin penetration enhancers comprises copolymerized acrylic and, optionally, vinyl monomers, to form a backbone polymer, to which are grafted polymeric moieties that do not absorb greater than 3% by weight of a skin-penetration enhancer under thermodynamic equilibrium at 25.degree. C. if independently introduced into an excess of the enhancer. Preferably, the grafted polymers are selected from the classes of polybutylene, polysaccharide, poly(ethyleneoxide/propyleneoxide), and polyamide polymers, and specific grafted polymers will depend on the specific enhancers used in a particular drug delivery system.

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Sarat C. Chattaraj and Roderick B. Walker, "Penetration Enhancer Classification", 1995, CRC Press, Inc., pp. 5-15.
Steven M. Wick, R. Ph., "Developing A Drug-In-Adhesive Design For Transdermal Drug Deliver", Adhesives Age, Sep. 1995, pp. 18-24.

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