Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Patent
1991-08-07
1993-02-16
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
424448, 424449, 424447, A61F 1300
Patent
active
051869381
ABSTRACT:
An adhesive bilayer transdermal dosage system capable of sustained release of a pharmaceutically active drug to the skin of a human patient having a first component layer which is a pharmaceutically active drug-containing essentially planar sheet of an at least partially cross-linked acrylic adhesive. The planar sheet is formed of a flexible self-supporting cross-linked acrylate of sufficient adhesivity, durability and strength whereby intimate diffusional contact with the skin of the patient is maintained for a period of at least about 24 hours without destruction of the physical integrity of the sheet. The sheet is capable of retaining, dispersed therein, sufficient pharmaceutically active drug to deliver to the skin a pharmaceutically effective amount of the drug over a 24-hour period without dissolution of the at least partially crosss-linked acrylic adhesive. The system also contains a second component layer intimately adhered to one side of the first component layer. The second component layer is resistant to the passage of the pharmaceutically active drug from the first component layer. Methods for making the first component layer and dosage system are also disclosed.
REFERENCES:
patent: 3742951 (1973-07-01), Zaffaroni
patent: 3896789 (1975-07-01), Trancik
patent: 4310509 (1982-01-01), Berglund et al.
patent: 4374164 (1983-02-01), Blank
patent: 4390530 (1983-06-01), Nagai et al.
patent: 4421737 (1983-12-01), Ito et al.
patent: 4482534 (1984-11-01), Blank
patent: 4608249 (1986-08-01), Otsuka et al.
Questel John M.
Sablotsky Steven
Thompson James A.
Dicker Eric S.
Horne Leon R.
Key Pharmaceuticals, Inc.
Maitner John J.
Page Thurman K.
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