Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-07-27
1996-12-10
Weimar, Elizabeth C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 2, 514 4, 530362, 530363, 530366, 530830, 424 77, 424 7802, 424 7806, 4241791, 4241931, 4241941, 424422, 424423, 424428, 525 541, A61K 3800, A61K 3900, C07K 100
Patent
active
055831141
ABSTRACT:
This invention is related to an adhesive composition which may be used to bond or seal tissue in vivo. The adhesive composition is readily formed from a two component mixture which includes a first part of a protein, preferably a serum albumin protein, in an aqueous buffer having a pH in the range of about 8.0-11.0 and a second part of a water-compatible or water-soluble bifunctional crosslinking agent. When the two parts of the mixture are combined, the mixture is initially a liquid which cures in vivo on the surface of tissue in less than about one minute to give a strong, flexible, pliant substantive composition which bonds to the tissue and is absorbed in about four to sixty days. The adhesive composition may be used either to bond tissue, to seal tissue or to prevent tissue adhesions caused by surgery.
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Two-Component Fibrin Sealant Tisseel.RTM. Kit Brochure.
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Barrows Thomas H.
Lewis Terry W.
Truong Myhanh T.
Busse Paul W.
Griswold Gary L.
Kirn Walter N.
Minnesota Mining and Manufacturing Company
Mohamed Abdel A.
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