Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Patent
1996-07-17
1998-05-12
Phelan, D. Gabrielle
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
424449, A61F 1302
Patent
active
057501386
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE INVENTION
This application is a 371 of PCT/IB94/00416, filed Dec. 13, 1994.
The present invention relates to an adhesive patch for the delayed transdermal administration of a medication, generally called a patch, which comprises in general a reservoir or a matrix containing said medication, as well as a removable protective strip, this protection being adapted to be removed just before placing the adhesive patch on the skin of the patient.
BACKGROUND OF THE INVENTION
Such a patch is well known and already used for the transdermal administration of different types of medications such as nitroglycerine, entofenamate, estradiol, scopolamine, dinitrate isorbide, clonidine, fentanyl, nicotine, etc., as described in the article by Richard W. Baker in "Controlled Released of Biologically Active Agents", J. Wiley & Sons, New York (1987), p. 239-45. There exist several types of such patches, also as disclosed in the above document, which also recites the advantages and drawbacks of this path of administration. In short, they can be divided into two large categories: (a) those which have a chamber serving as a reservoir for the medication, the latter being freed after removal of the protective strip before sticking the patch on the skin, either directly or through a microporous membrane, and (b) those which comprise a porous matrix, for example of silicone rubber or cellulosic ester, containing the medication which will diffuse into the skin from this support once the patch is in service position. Of course, other modifications of these patches are possible, for example by combining the two principal types above.
With most of the patches known at present, the administration of medication begins immediately after the protective band has been removed and the patch stuck to the skin, the speed of administration being of course a function particularly of the structure and of the nature of the porous membrane and/or of the support, as well as of the medication to be administered.
However, this peculiarity has been seen to be inconvenient when it is desired that this administration be delayed after emplacement of the patch. This is the case for example in the treatment of angina of the chest by means of nitroglycerine. Thus, an important element of this treatment is to be able to administer the nitroglycerine just before the client awakes, to prevent the effects of chest angina. It is therefore desirable in practice to have a patch whose effect is delayed for example 6 to 8 hours after its application.
The above object is at least partially achieved by transdermal administration systems disclosed in EP-A-0 199 362 and EP-A-0 249 343, which comprise means to delay said administration after emplacing the patch, in the form of an impermeable membrane device coacting with the reservoir or the matrix containing the medication to be administered, this device being so made that it becomes permeable in a delayed way by modification of its physico-chemical structure under the influence of an external stimulus.
However, the delay means such as are described in these two above documents have certain drawbacks, particularly for example the fact that the external stimulus is constituted by the body moisture, which is difficult to control, or else that the delaying effect is obtained by a phenomenon of diffusion through a membrane, which requires the use of relatively thick membranes for a delay of several hours.
SUMMARY OF THE INVENTION
Thus, the object of the present invention consists in providing an adhesive patch of the type recited, or patch, whose administration of the medication contained in this patch will be delayed in time, for example by several minutes or hours to several days, and which do not have the above drawbacks.
The adhesive patch for the transdermal administration of a medication, according to this invention and seeking to achieve the mentioned object, comprises a reservoir or a matrix containing said medication and an impervious membrane device coacting with said reservoir or matrix, this devi
REFERENCES:
patent: 4921757 (1990-05-01), Wheatley et al.
patent: 5273756 (1993-12-01), Fallon et al.
patent: 5284660 (1994-02-01), Lee et al.
patent: 5362308 (1994-11-01), Chien et al.
Graetzel Michael
Poscio Patrick
Saaman Ary
Phelan D. Gabrielle
Westonbridge International Limited
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