Adhesive for percutaneous administration

Details Adhesive for percutaneous administration Adhesive for percutaneous administration

1989-05-23

1991-03-05

Page, Thurman

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424449, A61M 3700

Patent

active

049976567

ABSTRACT:
An adhesive for percutaneous administration having a drug-containing layer composed of a base component mainly comprising a heat-sensitive and water-sensitive amphiphilic polymer and a drug incorporated in the base component. The amphiphilic compound has a characteristic hydrophobicity-hydrophilicity tapered structure, and a variety of liquid or solid or lipophilic (hydrophobic) or hydrophilic drugs of a broad range can stably be dissolved or dispersed therein. The drug in the drug-containing layer remains stable without being released or diffused while the adhesives are stored, and upon application to the skin, the drug is gradually released and diffused into the skin with high availability in a specifically controlled pattern. The present adhesive is especially advantageous for endermic presentation of a slight amount of a substance of high physiological activity which is unstable and is easily decomposed by heat or water.

REFERENCES:
patent: 4202880 (1980-05-01), Fildes et al.
patent: 4235988 (1980-11-01), Fildes et al.
patent: 4762899 (1988-08-01), Shikinami

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