Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Patent
1996-10-21
1999-01-12
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
424434, 424435, A61K 900, A61F 1300
Patent
active
058583793
DESCRIPTION:
BRIEF SUMMARY
The invention relates to an adhesive for dental prostheses.
Adhesives for dental prostheses are used to match dentures to the mucous membrane of the soft parts of the palate and to the gingival furrows with a tight and adhering fit, or at least to improve the match. The adhesive is applied to the denture, which is then inserted in the mouth. Saliva moistens the surface of the adhesive layer and in this way causes the adhesive to swell, which also develops the adhesive force.
The adhesive strength and duration of adhesion are decisive parameters. The mechanisms which are responsible for the holding action are highly complex. The viscosity of the carrier base substance and as a consequence of the finished product play an important role. Carrier base substances which are used are, inter alia, paraffin oil, Vaseline (petrolatum), waxes etc., which are diluted with polyethylene glycol, glycerol or the like as required and make up about 20 to 60% of the finished product in total. When compiling the formula, efforts are made to provide a medium for the crevice space which has as constant as possible an action and likewise constant flow properties.
The viscosity is primarily determined by the overall formula, that is to say by the active compounds and carriers in their entirety in the adhesive. There are a large number of compositions, each of which are adapted to various applications.
For example, DE-A 21 33 709 discloses a process for the preparation of an adhesive cream for dental prostheses in which a strong adhesive force is achieved by drying the adhesive very homogeneously to a moisture content of 10%.+-.1% and then comminuting it to a fineness of 50 um.
The problem of removing an adhesive from denture plates, where furthermore it should be possible to press this adhesive out of a tube without applying great force, is solved according to DE-A 37 15 100 by using a resin of low softening point which is chosen from polyvinyl acetate resins and naturally occurring chichle gum and comprises at least one compound having one or more polyoxypropylene groups.
EP-A 0 073 850 proposes providing the adhesive substances at least partly with a coating which dissolves only slowly in saliva. As a result, the adhesive strength is retained over a long period of time, since any adhesive substances rinsed out by saliva are replaced by those from which the coating has just been dissolved.
EP-A 0 122 481 proposes an adhesive which comprises a mixture of copolymers of alkyl vinyl ether/ maleic anhydride salts, for example 3Ca:1Na, and sodium carboxymethyl-cellulose with a carrier of a paraffin oil which has been thickened with polyethylene having a low molecular weight in the range from 1,000 to 21,000. An adhesive which has considerably improved adhesive properties at an oral temperature of 37.degree. C. is thus provided.
In addition to creamy and gelatinous adhesives, liquid adhesives have also been developed, in particular those based on paraffin oil, as disclosed, for example, in U.S. Pat. No. 4,280,936. Such adhesives present, in particular, the problem of being washed out by saliva on the one hand and by drinks on the other hand. It has been proposed to use sodium carboxymethyl-cellulose and ethylene oxide polymers in a ratio of 3:1. In this procedure, the polyethylene is first mixed into the paraffin oil at a temperature of about 90.degree. C. and the mixture is then cooled to 45.degree. C., after which the sodium carboxymethyl-cellulose is added. The mixture thereby slowly cools further to 35.degree. C. or below.
U.S. Pat. No. 4,542,168 proposes the use of partly neutralized and partly crosslinked polyacrylic acid, to which a hydrophilic polymer is added, in an adhesive. This composition is said to result, in particular, in the adhesive properties being retained for a longer period than usual.
In order to reduce the viscosity of a gel used as the carrier base substance, U.S. Pat. No. 4,495,314 proposes the use of sorbitan monostearate in a content of 0.25 to 2.25% by weight of the gel, in addition to a paraffin oil and a
REFERENCES:
patent: 4495314 (1985-01-01), Keegan
patent: 5024701 (1991-06-01), Desmarais
Hansen & Rosenthal, Pionier.RTM. PLW Salben-Cremegrundlage, 1989, Hamburg, Germany.
Knollman Rainer
Reuss Mira
Page Thurman K.
Reckitt & Colman Inc.
Shelborne Kathryne E.
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