Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Processes of preparing a desired or intentional composition...
Patent
1993-12-20
1998-02-10
Merriam, Andrew E C
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Processes of preparing a desired or intentional composition...
523118, 604307, 424448, 514635, 5147724, 528905, 602 48, 602 52, 602 54, A61L 1503, A61F 1300
Patent
active
057170053
DESCRIPTION:
BRIEF SUMMARY
This invention relates to adhesive compositions and to adhesive products. More particularly, the invention relates to medicated adhesive compositions and to products coated therewith.
Adhesive products containing a releasable medicament in the adhesive are known. The advantage of having a medicament, such as an anti-bacterial agent, in the adhesive is that the medicament is delivered to the site for release and use when the adhesive is applied eg. as part of a wound dressing. By providing a vehicle from which such medicaments as anti-bacterial agents can be released in a sustained manner, the area can be maintained free from bacterial infection. A known medicated adhesive product containing an antibacterial agent is sold under the trade name "OpSite CH" By T. J. Smith and Nephew Limited. The antibacterial incorporated into the adhesive layer is chlorhexidine acetate.
Chlorhexidine gluconate is also a well known antibacterial agent. However, because it is a extremely hygroscopic material its use is limited and in many applications it can only be used as a 20% aqueous solution, which is commercially available. In our researches we have found that it has only been possible to use gluconate solutions in adhesive formulations in amounts not exceeding about 3% by weight of chlorhexidine gluconate since at levels much above this the tack properties of the adhesive are adversely affected.
We have now found it possible to prepare chlorhexidine gluconate-containing adhesive compositions having higher levels of anti-bacterial activity and acceptable adhesive values then has been hitherto available.
Thus in accordance with the invention, there is provided an adhesive composition, suitable for medical applications, comprising an adhesive having dispersed therein solid particles of chlorhexidine gluconate, wherein said particles have a particle size of less than 125 .mu.m and at least about 30% by volume of the particles have a particle size of not less than 5 .mu.m.
Particles used in the invention which have a particle size of less than 125 .mu.m are particles which will pass through a 125 .mu.m mesh screen.
The solid form of chlorhexidine gluconate may be obtained by freeze-drying aqueous solutions of the gluconate, eg the commercially available 20% aqueous solution. The particle size of the freeze dried material is usually of a suitable size that the material requires no further comminution prior to incorporation into the adhesive mass.
The adhesives used in the invention may be any of those medically acceptable adhesives which are compatable with the gluconate. In particular the adhesive material should not contain groupings, such as free acid groups, which will react with the gluconate and thus render it unavailable for release. Suitably, the adhesive is one which is hydrophilic in nature.
Apt adhesives for use in the adhesive composition of the invention may include acrylic adhesives and adhesives based on polyvinyl ethers. A preferred acrylic adhesive is described in European Patent Publication No. 35399. A typical polyvinyl ether adhesive composition suitable for use in the present invention is that described as adhesive composition A in UK Patent specification No. 1280631.
The amount of chlorhexidine gluconate that is present in the adhesive can range up to 10% by weight of the weight of the composition without adversely affecting the tack of the adhesive. Thus amounts of chlorhexidine gluconate can be included which would exhibit bactericidal properties as well as bacteriostatic properties. Hitherto it has not been possible to include more than about 3% by weight chlorhexidine gluconate, as an aqueous solution, before the adhesive surface becomes deadened. At such low levels the anti-bacterial activity is restricted to that of bacteriostatic activity and with such adhesive compositions little or no bactericidal activity is observed.
We have also found that, on a weight for weight basis, adhesives based on solid gluconate have superior anti-bacterial properties than those adhesives based on chlorhexidine glucon
REFERENCES:
patent: 5035687 (1991-07-01), Sandbank
World Patents Index (Latest), Week 9016, AN.dbd.90-121106, Derwent Publications Ltd., London, GB & JP,A2073013, 13 Mar. 1990.
Merriam Andrew E C
Smith & Nephew plc
LandOfFree
Adhesive compositions and products does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Adhesive compositions and products, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Adhesive compositions and products will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2077853