Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-04-29
1996-07-02
Chang, Ceila
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514210, 514212, 514255, 514278, 514376, 540200, 540362, 540603, 544369, 546 18, 546229, 548229, 548962, A61K 3142, A61K 31445, C07D41306
Patent
active
055322557
ABSTRACT:
Compounds of the formula ##STR1## in which R.sup.1, X and Y have the meanings defined herein, and their salts, inhibit the binding of fibrinogen to the fibrinogen receptor and can be used for treating thrombosis, stroke, cardiac infarction, inflammations, arteriosclerosis, osteoporosis and tumors.
REFERENCES:
patent: 3687965 (1972-08-01), Fauran et al.
patent: 4886794 (1989-12-01), Walsh
patent: 4970217 (1990-11-01), Prucher et al.
patent: 5084466 (1992-01-01), Alig et al.
patent: 5086055 (1992-02-01), Walsh
patent: 5232931 (1993-08-01), Prucher et al.
Ruoslahti et al "New Perspective in Cell Adhesion: RGD and Integrins" Science 238 491-496 (1987).
Bajnsz et al "High Active and Selective Anticoagulants" J. Med. Chem. 33 pp. 1729-1735 (1990).
Hartman et al "Non-Peptide Fibrinogen Receptor Antagonists" J. Med. Chem. 35 4640-4642 (1992).
Born. Nature, 194(4832):927-929 (Jun. 9, 1962).
Bernotat-Danielowski Sabine
Gante Joachim
Juraczyk Horst
Melzer Guido
Prucher Helmut
Chang Ceila
Merck Patent Gesellschaft mit beschrankter Haftung
LandOfFree
Adhesion receptor antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Adhesion receptor antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Adhesion receptor antagonists will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1506696