Adhesion molecule

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

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4241841, 4242771, 514 2, 530300, 530324, 530325, 530326, 530327, 530328, 530350, 530380, 530395, 530827, 530828, 530829, 530837, 530838, 930 10, A61K 3900, A61K 3804, A61K 3808, A61K 3810

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058635408

ABSTRACT:
The present invention relates, in general, to a method of treating inflammation or inhibiting cancer cell metastasis. In particular, the present invention relates to a method of suppressing T cell activation, inhibiting CD44-mediated cell adhesion and CD44-monocyte IL1 release, treating inflammation, and transporting a drug to a site of inflammation.

REFERENCES:
patent: 5002873 (1991-03-01), St. John et al.
patent: 5108904 (1992-04-01), Landay
Avrameas, "Coupling of Enzymes to Proteins with Glutaraldehyde. Use of Conjugates for the Detection of Antigens and Antibodies", Immunochemistry 6:43-53 (1969).
Aruffo et al, "CD44 is the Principal Cell Surface Receptor for Hyaluronate", Cell 61:1303-1313 (1990).
Arch et al, "Participation in Normal Immune Responses of a Metastasis-Inducing Splice Variant of CD44", Science 257:682-685 (1992).
Kahn, "Adhesion Protein Studies Provide New Clue to Metastasis", Science 257:614 (1992).
Stamenkovic et al, "The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluraonate-bearing cells", EMBO Journal 10(2):343-348 (1991).
Dougherty et al, Moleculear Cloning of CD44R1 and CD44R2, Two Novel Isoforms of the Human CD44 Lymphocyte `Homing` Receptor Expressed by Hemopoietic Cells, Terry Fox Lab. 15:54 (1991).
Gunthert et al, "A New Variant of Glycoprotein CD44 Confers Metastatic Potential to Rat Carcinoma Cells", Cell. 65:13-24 (1991).
Sy et al, "Distinct Effects of Two CD44 Isoforms on Tumor Growth In Vivo", J. Exp. Med. 174:859-866 (1991).
Hofmann et al, CD44 Splice Variants Confer Metastatic Behavior in Rats: Homologous Sequences Are Expressed in Human Tumor Cell Lines, Cancer Research 51:5292-5297 (1991).
Jackson et al, "Multiple Variants of the Human Lymphocyte Homing Receptor CD44 Generated by Insertions at a Single Site in the Extracellular Domain", J. of Biological Chemistry 267(7):4732-4739 (1992).
Goldstein et al, "A Human Lymphocyte Homing Receptor, the Hermes Antigen, is Related to Cartilage Proteoglycan Core and Link Proteins", Cell. 56:1063-1072 (1989).
Haynes et al, "CD44-A molecule involved in leukocyte adherence and T-cell activation", Immunology Today 10(12):423-428 (1989).
Wolffe et al, "The cDNA Sequence of Mouse Pgp-1 and Homolgoy to Hyman CD44 Cell Surface Antigen and Proteoglycan Core/Link Proteins", J. of Biological Chemistry 265(1):341-347 (1990).
Haynes et al, "The Transmembrane Hyaluronate Receptor (CD44): Multiple Functions, Multiple Forms", Cancer Cells 3(9):347-350 (1991).
Ware et al, "Characterization of the Surface Topograph and Putative Tertiary Structure of the Human CD7 Molecule", J. of Immunology 143(11):3632-3640 (1969).
Haynes et al, "Measurement of an Adhesion Molecule as an Indicator of Inflammatory Disease Activity", Arthritis and Rheumatism 34(11):1434-1443 (1991).
Culty et al, "The Hyaluronate Receptor is a Member of the CD44 (H-CAM) Family of Cell Surface Glycoproteins", The Journal of Cell Biology 111(6/Pt.1):27655-2774 (1990).
Lesley et al, "CD44 can be activated to function as an hyaluronic acid receptor in normal murine T cells", Eur. J. Immunol. 11:2719-2723 (1992).
Lesley et al, Binding of Hyaluronic Acid to Lymphoid Cell Lines Is Inhibited by Monoclonal Antibodies against Pgp-1 (Experimental Cell Research 187:224-233 (1990).
Miyake et al, "Hyaluronate Can Function as a Cell Adhesion Molecule and CD44 Participates in Hyaluronate Recognition", J. Exp. Med. 172:69-75 (1990).
Lesley et al, "Requirement for Hyaluronic Acid Binding by CD44: A Role for the Cytoplasmic Domain and Activation by Antibody", J. Exp. Med. 175:257-266 (1992).
Peach et al, "Identification of Hyaluronic Acid Binding Sites in the Extracellular Domain of CD44", The Journal of Cell Biology 122(1):257-264 (1993).
Goetinck et al, "The Tandemly Repeated Sequences of Cartilage Link Protein Contain the Sites for Interaction with Hyaluronic Acid", The Journal of Cell Biology 105:2403-2408 (1987).
He et al, "Molecular Isoforms of Murine CD44 and Evidence That the Membrane Proximal Domain Is Not Critical for Hyaluronate Recognition", The Journal of Cell Biology 119(6):1711-1719 (1992).
Seiter et al, "Prevention of Tumor Metastasis Formation by Anti-Variant CD44", J. Exp. Med. 177:443-455 (1993).
Heider et al, "A Human Homologue of the Rat Metastasis-associated Variant of CD44 Is Expressed in Colorectal Carcinomas and Adenomatous Polyps", The Journal of Cell Biology 120(1):227-233 (1993).
Koopman et al, "Activated Human Lymphocytes and Agressive Non-Hodgkin's Lymphomas Express a Homologue of the Rat Metastasis-associated Variant of CD44", J. Exp. Med. 177:897-904 (1993).
Thomas et al, "CD44H Regulates Tumor Cell Migration on Hyaluronate-coated Substrate", The Journal of Cell Biology 118(4):971-977 (1992).
Turley et al, "Hyaluronan and a Cell-associated Hyaluronan Binding Protein Regulate the Locomotion of Ras-transformed Cells", The Journal of Cell Biology 112(5):1041-1047 (1991).
Kumar, V. et al. Proc. Natl. Acad. Sci USA 87:1337-1341, 1990.
Haynes, B.F. Springer Sum. Immunopatnol. 11:163-185, 1989.
Cohen, J. Science 262(5):841-843, Nov. 1993. Pgp-1 Antigens in Man Recognize the Hermes Class of Lymphocyte Homing Receptors", The Journal of Immunology 142(6):2046-2051 (1989).
Hale et al, "CD44 Antibody Against In(Lu)-Related p80, Lymphocyte-Homing Receptor Molecule Inhibits the Binding of Human Erythrocytes to T Cells", The Journal of Immunology 143(12):3944-3948 (1989).
Denning et al, "Antibodies Against the CD44 p80, Lymphocyte Homing Receptor Molecule Augument Human Peripheral Blood T Cell Activation", The Journal of Immunology 144(1):7-15 (1990).
Miyake et al, "Monoclonal Antibodies to Pgp-1/CD44 Block Lympho-Hemopoiesis in Long-Term Blone Marrow Cultures", 171:477-488 (1990).
Cohen, Jon, "Cancer Vaccines Get a Shot in the Arm", Science 262:841-843 (1993).
Haynes et al, "Differentiation of Human T Lymphocytes: 1. Acquisition of a Novel Human Cell Surface Protein (p80) During Normal Intrathymic T Cell Maturation", The Journal of Immunolgy 131(3):1195-1200 (1983).
Telen al, "Human Erythrocyte Antigens" Regulation of Expression of a Novel Erythrocyte Surface Antigen by the Inhibitor Lutheran In(Lu) Gene, J. Clin. Inves. 71:1878-1886 (1983).
"Biochemicals Organic Compounds for Research and Diagnostic Reagents" Sigma Catalog, pp. 1118-1119 (1992).
Fundamental Immunology, Third Edition, William E. Paul, M.D., Editor, Raven Press, New York, Ch. 8, p. 242.
Guo et al, "HIV-Induced Loss of CD44 Expression in Monocytic Cell Lines", The Journal of Immunology 151(4):2225-22236 (1993).
Rivadeneira et al, "Inhibition of HIV Type 1 Infection of Mononuclear Phagocytes by Anti-CD44 Antibodies", AIDS Research and Human Retroviruses 11(5):541-546 (1995).
Willerford et al, "Simian Immunodeficiency Virus is Restricted to a Subset of Blood CD4+ Lymphocytes that Includes Memory Cells", The Journal of Immunology 144(10):3779-3783 (1990).
Matsushita et al, "Selective Killing of HIV-Infected Cells by Anti-gp 120 Immunotoxins", AIDS Research and Human Retroviruses 6(2):193-203 (1990).
Nicholson et al, "In Vitro of Human Monocytes With Human T Lymphotropic Virus Type III/Lymphadenopathy-Associated Virus (HTLV-III/LAV)", The Journal of Immunology 137(1):323-329 (1986).
Hirsch et al, "Therapy for Human Immunodeficiency Virus Infection", The New England Journal of Medicine 1686-1695 (1993).
Fahey et al, "Status of immune-based therapies in HIV infection and AIDS", Clin. exp. Immunol. 88:1-5 (1992).
Edgington, Stephen M., "How Sweet It Is: Selectin-Mediating Drugs", Bio/Technology 10:383-389 (1992).
Shaffer, Marjorie, "Drug giants, start-ups target adhesion molecules, key to inflammatory disease", Biotechnology Newswatch, p. 9, Oct. 4, 1993.
Harris et al, "Therapeutic antibodies--the coming of age", TIBTECH 11:42-44 (1993).

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