Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-10-30
2007-10-30
Fredman, Jeffrey (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100
Reexamination Certificate
active
10776211
ABSTRACT:
The present invention relates to a method for identifying individuals with Parkinson's disease and/or individuals at risk for developing Parkinson's disease, comprising screening nucleic acids from the individual for a mutation in the ADH1C gene, as well as different uses thereof.
REFERENCES:
Buervenich et al. A rare truncating mutation in ADH1C (G78Stop) shows significant association with Parkinson's disease in a large international sample. Arch. Neurol. (2005) 62(1): 74-78.
Schmitt et al. The ADH1C stop mutation in multiple system atrophy patients and health probands in the United Kingdom and Germany. Mov. Disorders (2006) available online in advance of print on Sep. 7, 2006, pp. 1-2.
Buervenich et al. Alcohol dehydrogenase alleles in Parkinson's disease. Mov. Disorders (2000) 15: 813-818.
Tan et al. Alcohol dehydrogenase polymorphism and Parkinson's disease. Neuroscience Lett. (2001) 305: 70-72.
Burvenich Silvia
Carmine Andrea
Galter Dagmar
Olson Lars
Sydow Olof
AstraZeneca AB
Fredman Jeffrey
Thomas David C.
Young & Thompson
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