Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-10-09
1998-03-31
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 68, 514 70, 514 81, 536 256, 536 265, 536 274, 544264, A61K 3170, C07H 1919, C07H 1920
Patent
active
057338906
ABSTRACT:
Novel adenylate analogs having the following formula are synthesized in the present invention, which are found active against herpes simplex viruses: ##STR1## wherein R.sup.1 is hydroxyl, C.sub.1 -C.sub.4 alkoxy, an amino ester radical of --NHR.sup.3 COOR.sup.4, wherein R.sup.3 is a bivalent C.sub.1 -C.sub.4 saturated hydrocarbon and R.sup.4 is C.sub.1 -C.sub.4 alkyl; and R.sup.2 is hydroxyl, --O.sup.+ NH.sub.4 or ##STR2##
REFERENCES:
Hakimelahi et al., "Design Synthesis, and Structure-Activity Relationship of Novel Dinucleotide Analogues as Agents Against Herpes and Human Immunodeficiency Viruses," J. Medicinal Chem., 38(23), 4648-4659 (Nov. 10, 1995).
Rosenberg et al., "Phosphonylmethoxyalkyl and Phosphonylalkyl Derivatives of Adenine," Coll. Czech. Chem. Comm., 53(11B), 2753-2777 (Nov. 1988).
Hakimelahi Gholam H.
Hwu Jih Ru
Moosavi-Movahedi Ali A.
Sadeghi Majid M.
Tsay Shwu-Chen
Crane L. Eric
Kight John
National Science Council
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