Adenyl cyclase derivatives and their biological uses

Details Adenyl cyclase derivatives and their biological uses Adenyl cyclase derivatives and their biological uses

1989-10-25

1993-02-02

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435232, 4351721, 4351723, 935 10, 935 14, 536 232, C12P 2106, C12N 988, C12N 1500, C07H 1512

Patent

active

051837455

ABSTRACT:
The adenyl cyclase derivatives are atoxic derivatives in which one or several amino acids are different from those present in the toxic protein, the antibodies formed against these derivatives recognize, however, the toxic protein. These derivatives can be used as vaccines.

REFERENCES:
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Glaser et al., "The Calmodulin-Sensitive Adenylate Cyclase of Bordetella Pertussis: . . . " Mol. Microb. 1988 2 (1): 19-30.
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Glaser et al., Indentification of Residues Essential for Catalysis and Binding of Calmodulin in Bordetella Pertussis Adenylate Cyclase by Site-Directed Mutagenesis, EMBO J. 8(3):967-972 (1989).
Au et al., Site-Directed Mutagenesis of Lysine 58 in a Putative ATP-Binding Domain of the Calmodulin-Sensitive Adenylate Cyclase from Bordetella Pertussis Abolishes Catalytic Activity, Biochemistry, 28:2772-2776 (1989).

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