Adenoviruses having modified fiber proteins

Details Adenoviruses having modified fiber proteins Adenoviruses having modified fiber proteins

1993-08-13

1996-08-06

Fleisher, Mindy

Chemistry: molecular biology and microbiology

Vector, per se

424 931, 424 932, 536 234, 536 2372, 935 22, 935 32, 935 57, C12N 1586, C12N 1562, C12N 1534, A61K 4800

Patent

active

055433286

ABSTRACT:
An adenovirus wherein the adenovirus fiber protein includes a ligand which is specific for a receptor located on a desired cell type. The adenovirus may have at least a portion of the adenovirus fiber protein removed and replaced with a ligand which is specific for a receptor located on a desired cell type, or the adenovirus may include a fusion protein of the adenovirus fiber protein and the ligand. Such an adenovirus may also include a gene(s) encoding a therapeutic agent(s) and may be "targeted" in order to deliver such gene(s) to a desired cell type.

REFERENCES:
B. N. Fields et al., Eds. Fundamental Virology, 2nd Ed. New York: Raven Press, 1991, p. 779.
F. Levine et al. (1993) Am. J. Dis. Child 147(11):1167-1174.
D. Jolly (1994) Cancer Gene Therapy 1(1):51-64.
M. A. Kay et al. (1994) Proc. Natl. Acad. Sci. USA 91:2353-2357.
K. F. Kozarsky et al. (1994) J. Biol. Chem. 269:13695-13702.
T. A. G. Smith et al. (1993) Nature Genetics 5:397-402.
S. Connelly et al.. (1995) Human Gene Therapy 6:185-193.
V. Descamps et al. (1994) Human Gene Therapy 5:979-985.
L. D. Stratford-Perricaudet et al. (1990) Human Gene Therapy 1:241-256.
F. D. Ledley Human Gene Therapy (1991) 2:77-83.

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