Adenoviruses having altered hexon proteins

Details Adenoviruses having altered hexon proteins Adenoviruses having altered hexon proteins

1997-01-24

1999-07-13

Mosher, Mary E.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

4352351, 4353201, 435 691, 435456, 435466, 4241991, A61K 3576, A61K 4800, C12N 701, C12N 1586

Patent

active

059223154

ABSTRACT:
An adenovirus wherein at least one portion of at least one loop region of the hexon is changed. In one embodiment, the adenovirus, prior to modification, is of a first serotype, and at least a portion of at least one loop region of the hexon is removed and replaced with at least a portion of at least one loop region of the hexon of an adenovirus of a second serotype. Such modified adenoviruses do not have epitopes which are recognized by neutralizing antibodies to the unmodified adenovirus of the first serotype.

REFERENCES:
patent: 5543328 (1996-08-01), McClelland et al.
Roy et al (Journal of Virology 72:6875-6879, 1998.
Mastrangeli et al. Pediatrics Pulmonology, Supplement 12, p. 230, abstract 180, Sep. 1995.
Gene, vol. 13, pp. 311-317 (1981) Boursnell et al.
Current Topics in Microbilogy and Immunology, vol. 110, pp. 191-220 (1984) Wadell.
Science, vol. 232, pp. 1148-1151 (May 30, 1986) Roberts et al.
Journal of General Virology, vol. 75, pp. 133-139 (1994) Crompton et al.
Virology, vol. 205, pp. 439-452 (1994) Bailey et al.
Gene Therapy, vol. 3, pp. 154-162 (1996) Kass--Eisler et al.
Human Gene Therapy, vol. 7, pp. 79-87 (Jan. 1, 1996) Mastrangeli et al.
Journal of Virology, vol. 70, No. 4, pp. 2116-2123 (Apr. 1996) Gall et al.
Mautner, V. et al. Virology, vol. 131, pp. 1-10, 1983.
Crawford-Mikza, L. et al. Journal of Virology, vol. 70, p. 1836-1844, Mar. 1996.
Mautner, V. et al. Virology, vol. 139, pp. 43-52, 1984.
Pring-Akerblom, P. et al. Virology, vol. 212, pp. 232-236, 1995.
Crawford-Mikzsa, L. et al. Virology, vol. 224, pp. 357-367, 1996.
Verma, I. et al. Nature, vol. 389, Sep. 18, 1997, pp. 239-242.

Affiliated with

Also associated with

Rating

Adenoviruses having altered hexon proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Adenoviruses having altered hexon proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Adenoviruses having altered hexon proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2273293