Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2005-12-13
2005-12-13
McKelvey, Terry (Department: 1636)
Chemistry: molecular biology and microbiology
Vector, per se
C435S462000
Reexamination Certificate
active
06974694
ABSTRACT:
The invention claims a class of adenovirus vectors for delivering recombinases to a large number of cells of different origins, and methods for regulating the expression of a gene in transfected mammalian cells in culture and in cells of transgenic animals, comprising infecting said cells with an Ad vector encoding a recombinase whose target site is present at or adjacent to the gene, wherein the action of the recombinase regulates the expression of said gene.
REFERENCES:
patent: 4510245 (1985-04-01), Cousens et al.
patent: 4797368 (1989-01-01), Carter et al.
patent: 4920209 (1990-04-01), Davis et al.
patent: 4920211 (1990-04-01), Tibetts et al.
patent: 4959317 (1990-09-01), Sauer
patent: 5434066 (1995-07-01), Bebee et al.
patent: 5670488 (1997-09-01), Gregory et al.
patent: 5817492 (1998-10-01), Saito et al.
patent: 5882877 (1999-03-01), Gregory et al.
patent: 0300422 (1989-01-01), None
patent: WO 93/06223 (1993-04-01), None
patent: WO 93/19092 (1993-09-01), None
patent: WO 93/19191 (1993-09-01), None
patent: WO 94/08026 (1994-04-01), None
patent: WO 94/12649 (1994-06-01), None
patent: WO 95/27071 (1995-10-01), None
patent: WO 96/13597 (1996-04-01), None
patent: WO 97/25446 (1997-07-01), None
patent: WO 97/32481 (1997-09-01), None
Berkner, Current Topics in Microbiology and Immunology, vol. 158, pp. 39-66 (1992).
Anton et al., J. Virology, vol. 69, No. 8, pp. 4600-46060 (Aug. 1995).
Kanagae et al., Nucleic Acids Research, vol. 23, No. 19, pp. 3816-3821 (1995).
Graham, F.L., 1987. Growth of 293 cells in suspension culture. J. Gen. Virol. 68: 937-940.
Quantin, B., Leslie D. Pericaudet, Shahragim Tajbakhsh and Jean-Louis Mandel. 1992 Adenovirus as an expression vector in muscle cells in vivo. Proc. Nt'l. Acad. Sci. 89: 2581-2584.
Bett, A.J., Wael Haddara, Ludvik Prevec and Frank L. Graham. 1994. Proc. Nat'l. Acad Sci. 91: 8802-8806.
Rosenfeld, M.A. et al., 1992. In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium, Cell. 68: 143-155.
W.J. McGrory, D.S. Baulista and F.L. Graham. 1988. A simple techinque for the resue of early region 1 mutations into infectious human adenovirus type 5, Virology 163: 614-617.
Orkin et al., Report and recommendations of the panel to assess the NIH investment in research on gene therapy. Distributed by the National Institutes of Health, Bethesda, MD, Dec. 7, 1995.
Russ, Andreas P., et al. 1996. Self-deleting Retrovirus Vectors for Gene Therapy. J. of Virology, pp. 4927-4932.
Wang, P., Anton, F.L. Grahan, and S. Bacchetti. High Frequency recombination between loxP sites in human chromosomes mediated by an adenovirus vector expressing Cre recombinase. Somatic Cell and Molecular Genetics. vol. 21. 1995, pp 429-441.
Sauer, Brian and Nancy Henderson. 1998. Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1. Proc. Nat'l. Acad. Sci. USA 85: 5166-5170.
Gudrun Schiedner, et al., 1998. Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity. Nature Genetics 18: 180-183.
Manal A. Morsy, et al., 1998. An Adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene. Proc. Nat'l. Acad. Sci. USA 95: 7866-7871.
Parks, et al., 1996. A helper-dependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc. Nat'l. Acad. Sci. USA 93: 13565-13570.
Stephen Hardy, et al., 1997. Construction of Adenovirus Vector through Cre-lox Recombination. Jour. Virol. 71:3 1842-1849.
Metzger, D., J. Clifford, H. Chiba and P. Chambon. 1995. Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre protein. Proc. Nat'l. Acad. Sci. USA 92: 6991-6995.
Pichel, J.G., Lakso, and Westphal. 1993. Timing of SV40 oncogene activation by site-specific recombination determines subsequent tumor progression during murine lens development. Oncogene 8: 3333-3342.
Sauer, B.. 1994. Site-specific recombination: developments and application. Cur. Opin. Biotech. 5: 521-527.
Sauer, B. and N. Henderson. 1989. Cre-stimulated recombinatin of loxP-containing DNA sequences placed into the mammalian genome. Nucl. Acids Res. 17: 147-161.
Sauer, B., and N. Henderson. 1990. Targeted Insertion of exogenous DNA into the eukaryotic genome by the Cre-recombinase. The New Biologist 2: 441-449.
Sauer, B., M. Whealy, A. Robbins and L. Enquist. 1987. Site-specific insertion of DNA into a pseudorabies virus vector. Proc. Nat'l. Adac. Sci. USA 84: 9108-9112.
Smith A.J., M.A. Desousa, B. Kwabi-Addo, A. Heppell-Parton, H. Impey, and P. Rabbits. 1995. A site-directed chromosomal translocation induced in embryonic stem cells by Cre-loxP recombination. Nature Genetics 9: 376-385.
Rabbits, 1995. A site-directed chromosomal translocation induced in embryonic stem cells by Cre-loxP recombination. Nature Genetics 9: 376-385.
Sternberg, N., B. Sauer, R. Hoess, and K. Abremski. 1986. Bacteriophase P1 cre gene and its regulatory region; Evidence for multiple promotors and for regulation by DNA methylation. J. Mol. Biol. 187: 197-212.
Van Deursen, J. M. Fornerod, B. Van Rees, and G. Grosveld. 1995. Cre-mediated site specific translocation between non-homologous mouse chromosomes. Proc. Nat'l. Acad. Sci. USA 92: 7376-7380.
Mittal, S.K., McDermott, M.R., Johnson, D.C. Prevec, L., and F.L. Graham. 1993. Monitoring foreign gene expression by a human adenovirus-based vector using the firefly luciferase gene as a reporter. Virus Research, 28: 67-90.
Hanke, T., Frank L. Graham, Kenneth L. Rosenthal and David C. Johnson. 1991. Identification of an immunodomiman cytotoxic t-lymphocyte recognition site in glycoprotein B of herpes simplex virus by using recombinant adenovirus vectors and synthetic peptides. 1991. J. of Virology, 65: 1177-1186.
Anton, M., and F.I. Graham, 1995, Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein: a molecular switch for control of gene expression, J. Virol. 69: 4600-4606.
Araki, K., J. Araki, J.I. Miyazaki, and P. Vassali, 1995, Site-specific recombination of a transgene in fertilized eggs by transient expression of Cre recombinase. Proc. Nat'l. Acad. Sci. USA 92: 160-164.
Bett, A.J., I. Prevec, and F.L. Graham, 1993, Packaging capacity and stability of human adenovirus type 5 vectors, J. Virol. 67, 5911-5921.
Bett, AJ., W. Haddara, L. Prevec, and F.L. Graham, 1994, An efficient and flexible system for construction of adenivorus vectors with insertions of deletions in early region 1 and 3, Proc. Nat'l. Acad. Sci USA 91, 8802-8806.
Crystal, R.G., N.G. McElvancy, M.A. Rosenfield, C.S. Chu, A. Mastrangeli, J.G. Hay, S.L. Brody, H.A. Jaffe, N.T. Eissa, and C. Danel. 1994 Administration of an Adenivorus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis, Nature Genetics 8: 42-51.
Disanto, J.P., W. Mueller, D. Guy-Grand, A. Fischer, and K. Rajewsky, 1995, Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor chain, Proc. Nat'l. Acad. Sci. USA 92: 377-381.
Gage, P.J., B. Sauer, M. Levin and J.C. Glorioso, 1992, A cell-free recombination system for site-specific Integration of multigenic shuttle plasmids into the herpes simplex virus type 1 genome. J. Virol. 66: 5509-5515.
Graham, F.L. and L. Prevec, 1991, Manipulation of adenovirus vectors. In Murray E.J. (ed.), Methods in Molecular Biology, The Humana Press Inc. Clifton NJ vol. 7 (Gene Transfer and Expression Protocols): 109-128.
Graham, F.L. and L. Prevec, 1992, Adenovirus-based expression vectors and recombinant vacines in: Vaccines; New Approaches in Immunological Problems., ed. Ellis R.W. Butterworth-Heinemann, Boston, MA: 363-390.
Graham, F.L., J. Smiley, W.C. Russel, and R. Nairn. 1977. Characteristics of a human cell line transformed by DNA from human adenovirus type 5, J. Gen Virol. 36: 59-72.
Gu, J.H., D. Marth, P.C. Orban, H. Mossmann, and K. Rajewsky, 1994, Deletion of a DNA polymerase B gene segment in T cells using
Anton Martina
Bacchetti Silvia
Graham Frank L.
Muller William J.
Rudnicki Michael A.
AdVec, Inc.
Beusse Brownlee Wolter Mora & Maire, PA
Fischer Joseph
McKelvey Terry
Vogel Nancy T.
LandOfFree
Adenoviruses for control of gene expression does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Adenoviruses for control of gene expression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Adenoviruses for control of gene expression will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3509399