Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1995-03-24
1998-01-13
Stone, Jacqueline M.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
424 932, 4351723, 4352401, 4352402, 4353201, 514 44, A61K 4800, C12N 1500, C12N 500
Patent
active
057076189
ABSTRACT:
The present invention relates to novel adenovirus vectors for use in gene therapy which are designed to prevent the generation of replication-competent adenovirus (RCA) during in vitro propagation and clinical use. The invention also provides methods for the production of the novel virus vectors. These vectors maximize safety for clinical applications in which adenovirus vectors are used to transfer genes into recipient cells for gene therapy.
REFERENCES:
Zabner et al., Gene Therapy 3:458-465, 1996.
Armentano et al., Human Gene Therapy 6:1343-1353, 1995.
Krougliak et al., Human Gene Therapy 6:1575-1586, 1995.
Welsh et al., Human Gene Therapy 6:205-218, 1995.
Wadsworth et al., J. Cell Biochem. Supp. 21A, Abstract No. c6-450, 1995.
Setoguchi et al., Blood 84:2946-2953, 1994.
Engelhardt et al., Human Gene Therapy 5:1217-1229, 1994.
Armentano et al., J. Cell Biochem. Supp. 18A, Abstract no. DZ 102, 1994.
Wilkinson et al., Nucleic Acids Res. 20:2233-2239, 1992.
Rosenfeld et al., Cell 68:143-155, 1992.
Jolly, D., Cancer Gene Therapy 1:51-64, 1994.
Marshall, Science: 269:1050-1055, 1995.
Neve, Trends in Neuroscience 16(7):251-253, 1993.
Berkner, BioTechniques 6(7):616-629, 1988.
NIH, "Report and Recommendations . . . ", Dec. 7, 1995, pp. 1-40.
Vincent et al., Nature Genetics 5:130-134, 1993.
Descamps et al., Human Gene Therapy 5:979-985, 1994.
Stratford-Perricaudet et al., Human Gene Therapy 1:241-256, 1990.
Mitani et al., Human Gene Therapy 5:941-948, 1994.
Haddada et al., Human Gene Therapy 4:703-711, 1993.
Jaffe et al., Nature Genetics 1:372-378, 1992.
Zabner, J. et al., Nature Genetics 6:75-83, 1994.
Rich, D. et al.,Human Gene Therapy 4:461-476, 1993.
Zabner, J. et al., Cell 75:207-216, 1993.
Crystal, R.G. et al., Nature Genetics 8:42-51, 1994.
Bridge, E. et al., J. Virol. 63:631-638, 1989.
Huang, M. et al., J. Virol. 63:2605-2615, 1989.
Klessig, D. et al., Mol. Cell. Biol. 4:1354-1362, 1984.
Weinberg, D. et al., Proc. Natl. Acad. Sci. USA 80:5383-5386, 1983.
Armentano Donna
Romanczuk Helen
Wadsworth Samuel Charles
Genzyme Corporation
Milne Andrew
Stone Jacqueline M.
LandOfFree
Adenovirus vectors for gene therapy does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Adenovirus vectors for gene therapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Adenovirus vectors for gene therapy will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-324044